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PSMG1 Antibody

  • 货号：
    CSB-PA018921LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Jurkat whole cell lysate
      All lanes: PSMG1 antibody at 2µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 33, 31 kDa
      Observed band size: 33 kDa
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA018921LA01HU at dilution of 1:100
    • Immunofluorescent analysis of PC-3 cells using CSB-PA018921LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PSMG1 Polyclonal antibody
  • Uniprot No.：
    O95456
  • 基因名：
    PSMG1
  • 别名：
    PSMG1 antibody; C21LRP antibody; DSCR2 antibody; PAC1 antibody; Proteasome assembly chaperone 1 antibody; PAC-1 antibody; Chromosome 21 leucine-rich protein antibody; C21-LRP antibody; Down syndrome critical region protein 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Proteasome assembly chaperone 1 protein (91-200AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PSMG1 Antibody (CSB-PA018921LA01HU)，的标记方式是Non-conjugated。对于PSMG1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA018921LB01HU PSMG1 Antibody, HRP conjugated ELISA
    FITC CSB-PA018921LC01HU PSMG1 Antibody, FITC conjugated
    Biotin CSB-PA018921LD01HU PSMG1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.
  • 基因功能参考文献：
    1. RNA-seq evidence of biallelic expression of PSMG1 and 10 neighboring genes in at least one primary human tissue tested indicates that the expression of PSMG1 is uncoupled from the control of the maternally inherited 5mCpG imprints at the WRB differentially methylated region (DMR) in disomic controls or trisomy (Down syndrome) individuals. PMID: 27100087
    2. PSMG1 mutation is associated with Crohn's disease. PMID: 22593026
    3. Data show that an additive gene-gene interaction involving TLR4, PSMG1, TNFRSF6B and IRGM was identified with CD. PMID: 21079743
    4. PSMG1 gene expression is increased in classic variant of papillary thyroid carcinoma. PMID: 21509594
    5. The DSCR2 protein is associated with the endoplasmic reticulum; it is not an integral membrane protein and it is maintained on the cytoplasmic side of the ER by indirect interaction with the ER membrane or with another protein. PMID: 15590417
    6. Further, the results of intracellular localization studies and membrane fractionation assays indicate that DSCR2 is targeted to a cytoplasmic compartment as a soluble form. PMID: 15670775
    7. two chaperones, designated proteasome assembling chaperone-1 (PAC1) and PAC2, form a heterodimer and are involved in the maturation of mammalian 20S proteasomes PMID: 16251969
    8. DSCR2 was found to interact with PPARbeta and to inhibit it. PMID: 18793612

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  • 亚细胞定位：
    Cytoplasm. Endoplasmic reticulum.
  • 蛋白家族：
    PSMG1 family
  • 组织特异性：
    In the adult, detected in brain, colon, leukocytes, breast and testis. Widely expressed in the fetus. Also expressed in a variety of proliferating cell lines.
  • 数据库链接：

    HGNC: 3043

    OMIM: 605296

    KEGG: hsa:8624

    STRING: 9606.ENSP00000329915

    UniGene: Hs.473838