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  4. PTBP2 Antibody

PTBP2 Antibody

  • 货号：
    CSB-PA018950GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9UKA9
  • 基因名：
  • 别名：
    brPTB antibody; FLJ34897 antibody; MIBP antibody; Neural polypyrimidine tract binding protein antibody; Neural polypyrimidine tract-binding protein antibody; Neurally enriched homolog of PTB antibody; Neurally-enriched homolog of PTB antibody; nPTB 5 antibody; nPTB 6 antibody; nPTB 7 antibody; nPTB 8 antibody; nPTB antibody; nPTB5 antibody; nPTB6 antibody; nPTB7 antibody; nPTB8 antibody; Polypyrimidine tract binding protein 2 antibody; Polypyrimidine tract-binding protein 2 antibody; PTB antibody; PTB like antibody; PTB like protein antibody; PTB-like protein antibody; PTBLP antibody; PTBP 2 antibody; Ptbp2 antibody; PTBP2_HUMAN antibody; Splicing regulator antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PTBP2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation.; Reduced affinity for RNA.
  • 基因功能参考文献：
    1. It has been established that PTBP1 and PTBP2 are members of a family of cryptic exon repressors. PMID: 27681424
    2. PTBP1 and PTBP2 impaired autoregulation of SRSF3 in oral squamous cell carcinoma cancer cells. PMID: 26416554
    3. Data show that polypyrimidine tract-binding proteins nPTB and ROD1 interact with mitochondrial tRNA(Thr) in the cytoplasm outside of mitochondria. PMID: 26657638
    4. In T98G glioma cells, the level of sumoylated PTBP2 was reduced compared to that of normal brain cells. Overall, this study shows that PTBP2 is posttranslationally modified by SUMO1. PMID: 24286314
    5. MALAT1 binds to SFPQ releasing PTBP2 from the SFPQ/PTBP2 complex, the increased SFPQ-detached PTBP2 promotes cell proliferation and migration in colorectal cancer. PMID: 25025966
    6. Defining the multifunctional roles of PTB will contribute to the understanding of key regulatory events in gene expression. PMID: 24264039
    7. Changes in miR-223/PTBP2 pathway could contribute of abnormal splicing in chronic myeloid leukemia. PMID: 23174904
    8. Regulation of the mutually exclusive exons 8a and 8 in the CaV1.2 calcium channel transcript by polypyrimidine tract-binding protein. PMID: 21282112
    9. present fluorescence, NMR, and in vivo splicing data in support of a role of PTB in inducing RNA loops. We show that the RNA recognition motifs (RRMs) 3 and 4 of PTB can bind two distant pyrimidine tracts and bring their 5' and 3' ends in close proximity PMID: 20160105
    10. The nPTB proximal promoter, although rich in G+C content and presenting putative binding sites for the transcription factors Sp1, NF-1, NF-kB and Oct-1, lacks a typical TATA box. PMID: 16002244
    11. Study shows that PTB can function as an anti-repressor molecule to counteract the splicing inhibitory activity of SRp30c. PMID: 17548433

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Mainly expressed in brain although also detected in other tissues like heart and skeletal muscle. Isoform 1 and isoform 2 are specifically expressed in neuronal tissues. Isoform 3 and isoform 4 are expressed in non-neuronal tissues. Isoform 5 and isoform
  • 数据库链接：

    HGNC: 17662

    OMIM: 608449

    KEGG: hsa:58155

    STRING: 9606.ENSP00000412788

    UniGene: Hs.596061