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PTGES2 Antibody

  • 货号：
    CSB-PA018977GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9H7Z7
  • 基因名：
  • 别名：
    C9orf15 antibody; FLJ14038 antibody; Gamma interferon activated transcriptional element binding factor 1 antibody; GATE binding factor 1 antibody; GBF 1 antibody; GBF1 antibody; Membrane associated prostaglandin E synthase 2 antibody; MGC11289 antibody; Microsomal prostaglandin E synthase 2 antibody; mPGES 2 antibody; mPGES-2 antibody; PGES2 antibody; PGES2_HUMAN antibody; Prostaglandin E synthase 2 antibody; Prostaglandin E synthase 2 truncated form antibody; PTGES 2 antibody; PTGES2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PTGES2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro). The biological function and the GSH-dependent property of PTGES2 is still under debate. In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA).
  • 基因功能参考文献：
    1. Four single nucleotide polymorphisms in two genes in the PGE2 family, PTGES2 and PTGER4, were significantly associated with primary graft dysfunction after lung transplantation. PMID: 24467603
    2. high immunoreactivity of mPGES-2 in pyramidal neurons of AD brains indicates that it might have a potential role in the functional replacement of cytosolic PGES or inactive mPGES-1 in later stages of Alzheimer disease PMID: 19664621
    3. Up-regulation of prostaglandin E2 synthesis by interleukin-1beta in human orbital fibroblasts involves coordinate induction of prostaglandin-endoperoxide H synthase-2 and glutathione-dependent prostaglandin E2 synthase expression PMID: 11847219
    4. role in regulating interferon-gamma-dependent gene expression PMID: 12050152
    5. 110Cys is essential in the active site of membrane-associated prostaglandin E synthase-2 PMID: 12804604
    6. Transactivators GBF1 and CCAAT/enhancer-binding protein-beta physically interact to induce interferon-gamma-regulated transcription; a 37-aa long peptide derived from the GBF1 protein can associate with C/EBP-beta in an IFN-inducible manner. PMID: 15879117
    7. alphaTOS inhibits COX activity, thereby inhibiting PGE2 production in human lung epithelial cells PMID: 16714329
    8. study obtained evidence from two Caucasian study populations that the His298-allele of PTGES2 Arg298His confers to reduced risk of type 2 diabetes PMID: 17566096
    9. Carbonyl reductase-1 (CBR1), microsomal prostaglandin E synthase-1 and 2 (mPGES-1, mPGES-2), cytosolic prostaglandin E synthase (cPGES), aldoketoreductase (AKR1C1) and prostaglandin F synthase (AKR1C3) were all expressed in hair follicles. PMID: 17697149
    10. risk-reducing effects of the minor His allele of the prostaglandin E synthase 2 (PTGES2) Arg298His polymorphism could be mediated partly by lowered body mass index (BMI) PMID: 17979097
    11. all three terminal prostaglandin synthases, mPGES-1, mPGES-2, and cPGES, are over-expressed in human gliomas PMID: 19347995
    12. A marginal but significant influence of the PTGES2 298H single nucleotide polymorphism on BMI was found in a large population-based study. PMID: 19371221
    13. These results indicate that mPGES-1 and mPGES-2 may each play a role in colorectal cancer progression. PMID: 19412621

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  • 亚细胞定位：
    Golgi apparatus membrane; Single-pass membrane protein.; [Prostaglandin E synthase 2 truncated form]: Cytoplasm, perinuclear region.
  • 蛋白家族：
    GST superfamily
  • 组织特异性：
    Widely expressed. Expressed in the heart, including apex, inter-ventricular septum, both atria and ventricles, but not in the aorta. Also expressed in fetal heart. Detected in various regions of the brain: cerebellum; occipital, frontal and parietal lobes
  • 数据库链接：

    HGNC: 17822

    OMIM: 608152

    KEGG: hsa:80142

    STRING: 9606.ENSP00000345341

    UniGene: Hs.495219