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PTGR2 Antibody

  • 货号：
    CSB-PA007365
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of K562 cells using PTGR2 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q8N8N7
  • 基因名：
    PTGR2
  • 别名：
    15 oxoprostaglandin 13 reductase antibody; 15 oxoprostaglandin delta 13 reductase antibody; 15-oxoprostaglandin 13-reductase antibody; DKFZp686P10120 antibody; FLJ39091 antibody; FLJ99229 antibody; PGR 2 antibody; PGR2 antibody; PRG-2 antibody; Prostaglandin reductase 2 antibody; PTGR 2 antibody; PTGR2 antibody; PTGR2_HUMAN antibody; Zinc binding alcohol dehydrogenase domain containing 1 antibody; Zinc binding alcohol dehydrogenase domain containing protein 1 antibody; Zinc-binding alcohol dehydrogenase domain-containing protein 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human PTGR2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.
  • 基因功能参考文献：
    1. Silencing of PTGR2 expression enhances reactive oxygen species production, suppresses pancreatic cell proliferation, and promotes cell death through increasing 15-keto-PGE2. PMID: 26820738
    2. Functional data and clinical relevance for the role of PTGR2 in gastric cancer, are provided. PMID: 22998775
    3. Cloning and tissue distribution of a splicing variant ZADH1b. PMID: 15004468
    4. Besides targeting cyclooxygenase, indomethacin inhibits PTGR2 with a binding mode similar to that of 15-keto-PGE(2). PMID: 19000823
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    NADP-dependent oxidoreductase L4BD family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 20149

    OMIM: 608642

    KEGG: hsa:145482

    STRING: 9606.ENSP00000267568

    UniGene: Hs.632344