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PTOV1 Antibody

  • 货号：
    CSB-PA769809LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA769809LA01HU diluted at 1:200 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA769809LA01HU diluted at 1:200 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of Hela cells with CSB-PA769809LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PTOV1 Polyclonal antibody
  • Uniprot No.：
    Q86YD1
  • 基因名：
    PTOV1
  • 别名：
    PTOV1 antibody; ACID2 antibody; PP642 antibody; UNQ6127/PRO20092 antibody; Prostate tumor-overexpressed gene 1 protein antibody; PTOV-1 antibody; Activator interaction domain-containing protein 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Prostate tumor-overexpressed gene 1 protein (2-137AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PTOV1 Antibody (CSB-PA769809LA01HU)，的标记方式是Non-conjugated。对于PTOV1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA769809LB01HU PTOV1 Antibody, HRP conjugated ELISA
    FITC CSB-PA769809LC01HU PTOV1 Antibody, FITC conjugated
    Biotin CSB-PA769809LD01HU PTOV1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation.
  • 基因功能参考文献：
    1. The combination of PTOV1 expression level and HPV status provides more prognostic information compared with HPV status alone in early-stage human laryngeal squamous cell carcinoma. PMID: 26992242
    2. Studies indicate that the number of binding partners and associated cellular functions has increased and helped to identify prostate-tumor-overexpressed-1 (PTOV1) as regulator of gene expression at transcription and translation levels. PMID: 28029646
    3. this study takes the lead to demonstrate that the overexpressed PTOV1 plays a vital role in the tumorigenesis and progression of esophageal squamous cell carcinoma, and it is potentially a valuable prognostic predicator and new chemotherapeutic target for esophageal squamous cell carcinoma PMID: 28651486
    4. All the study samples showed a considerable decrease in PTOV1 expression in prostate cancer and HGPIN compared to morphologically normal glands. PMID: 27804940
    5. High PTOV1 expression was associated with invasive urothelial carcinoma. PMID: 26746655
    6. PTOV1 overexpression is associated with poor survival outcomes of nasopharyngeal carcinoma patients. PMID: 26305455
    7. PTOV1 protein abnormal expression might contribute to the malignant progression of epithelial ovarian cancer. PMID: 25270739
    8. Our study demonstrated that PTOV1 overexpression is correlated with increased aggressiveness of hepatocellular carcinoma and could be a prognostic biomarker for patients with HCC PMID: 25634174
    9. The study showed that PTOV1 is upregulated in breast cancer cell lines and clinical samples, and its expression was positively associated with progression and aggressiveness of breast cancer, suggesting that PTOV1 could serve as an independent prognostic marker. PMID: 24947166
    10. In prostate tumors, the overexpression of PTOV1 was associated with decreased expression of HEY1 and HES1, and this correlation was significant in metastatic lesions. PMID: 24684754
    11. RA-induced cancer cell cytotoxicity was significantly impaired by Zyxin or PTOV1. Overall, our findings suggest that Zyxin and PTOV1 should be considered as critical determinants in cancer therapy with retinoids PMID: 23321499
    12. alpha-Methyl-CoA racemase can be considered a more accurate marker than PTOV1 in the identification of high-grade prostatic intraepithelial neoplasia (HGPIN) and of prostate cancer. PMID: 22507319
    13. PTOV1 expression is associated to more aggressive human carcinomas and more significantly to bladder carcinomas suggesting that this protein is a potential new marker of aggressive disease in the latter tumors. PMID: 21181414
    14. MED25 and PTOV1 differentially modulate retinoic acid sensitivity in cancer cells depending on their expression levels. PMID: 21110951
    15. This protein, overexpressed in prostate cancer, shuttles between the cytoplasm and the nucleus and promotes entry into the S phase of the cell division cycle. PMID: 12598323
    16. PTOV1 assists flotillin-1 in its translocation to the nucleus and both proteins are required for cell proliferation. PMID: 15713644
    17. PTOV1 is overexpressed in high-grade prostatic intraepithelial neoplasia associated with cancer and is a potential marker for studying the carcinogenesis and progression of prostate cancer. PMID: 18451224

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Cell membrane. Cytoplasm, perinuclear region.
  • 蛋白家族：
    Mediator complex subunit 25 family, PTOV1 subfamily
  • 组织特异性：
    Expressed in brain, heart, kidney, liver, placenta, skeletal muscle and small intestine.
  • 数据库链接：

    HGNC: 9632

    OMIM: 610195

    KEGG: hsa:53635

    STRING: 9606.ENSP00000375717

    UniGene: Hs.587979