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  4. PTPN12 Antibody

PTPN12 Antibody

  • 货号：
    CSB-PA776978
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA776978(PTPN12 Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA776978(PTPN12 Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: 231 cells, K562 cells, Primary antibody: CSB-PA776978(PTPN12 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes
  • 其他：

产品详情

  • Uniprot No.：
    Q05209
  • 基因名：
    PTPN12
  • 别名：
    Protein tyrosine phosphatase G1 antibody; Protein tyrosine phosphatase non receptor type 12 antibody; Protein-tyrosine phosphatase G1 antibody; PTN12_HUMAN antibody; PTP PEST antibody; PTP-PEST antibody; PTPG1 antibody; Ptpn12 antibody; Tyrosine protein phosphatase non receptor type 12 antibody; Tyrosine-protein phosphatase non-receptor type 12 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human PTPN12
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:100-1:300
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2. Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248'.
  • 基因功能参考文献：
    1. identified a new phosphorylation-based substrate recognition mechanism of PTPN12 by CDK2, which orchestrated signaling crosstalk between the oncogenic CDK2 and HER2 pathways PMID: 28842430
    2. PTPN12 plasmid transfection increased PTPN12 mRNA and protein expressions, suppressed cell proliferation and migration, reduced EGFR level, and enhanced caspase 3 activity compared with control and empty plasmid groups. PMID: 29634414
    3. PTPN12, PTPRN and PTPN18 were independent prognostic factors in Hepatocellular Carcinoma. PMID: 29742497
    4. Here, solved is a crystal structure of the native PTPN12 catalytic domain with the catalytic cysteine (residue 231) in dual conformation (phosphorylated and unphosphorylated). PMID: 29278368
    5. this study, with a relative large population, showed that PTPN12 eQTL SNP may interact with HBV mutation on HCC risk. PMID: 27075395
    6. MyoVa-Ca(2+) channel interactions are required for proper long-range axon growth in developing spinal cord in vivo. PMID: 27134172
    7. PTP-PEST regulates EphA3 activation both by affecting cytoskeletal remodelling and through its direct action as a PTP controlling EphA3 phosphorylation. PMID: 26644181
    8. Study suggests that PTPN12 expression is a valuable prognostic biomarker for non-small cell lung cancer. PMID: 25868976
    9. PTPN12 expression decreases in human renal cell carcinoma PMID: 26537073
    10. The decrease expression of PTPN12 might be important in conferring a more aggressive behavior in NPC. Thus, PTPN12 expression may be used as a novel independent prognostic biomarker for patients with NPC. PMID: 25663493
    11. PTPN12 is potentially a methylation-silenced TSG for breast cancer that may play an important role in breast carcinogenesis and could potentially serve as an independent prognostic factor for invasive breast cancer patients. PMID: 23044628
    12. Decreased expression of PTPN12 correlates with tumor recurrence and poor survival of patients with hepatocellular carcinoma. PMID: 24475046
    13. these data suggest that PTP-PEST affects epithelial cell motility by controlling the distribution and phosphorylation of p120 and its availability to control Rho GTPase activity. PMID: 24284071
    14. The involvement of PTPN12 in the antioxidant response of breast cancer cells suggests that PTPN12 may represent a novel therapeutic target for this disease PMID: 23435421
    15. Overexpression of PTPN12 inhibited proliferation and migration in OSCC cells. PMID: 23733313
    16. MRNAs of PTPN12, MSH6, and ZEB1 orthologous genes from different animal species have binding sites for hsa-miR-1279 which consist of homologous oligonucleotides encoding similar human oligopeptides PMID: 23957009
    17. High expression of PTPN12 is associated with favorable disease free survival in esophageal squamous cell carcinoma patients. PMID: 22429674
    18. activated Ras induces extracellular signal-regulated kinase 1 and 2-dependent phosphorylation of PTP-PEST at S571, which recruits PIN1 to bind to PTP-PEST PMID: 21876001
    19. Using a genetic screen, study identifies the PTPN12 tyrosine phosphatase as a tumor suppressor in PMID: 21376233
    20. PTP-PEST functions as a suppressor of epithelial cell motility by controlling Rho GTPase activity and the assembly of adherens junctions. PMID: 20519451
    21. PTP-PEST actively contributes to the cellular apoptotic response and reveal the importance of caspases as regulators of PTPs in apoptosis. PMID: 17130234
    22. These data demonstrate that LPXN forms a signaling complex with Pyk2, c-Src, and PTP-PEST to regulate migration of prostate cancer cells. PMID: 17329398
    23. No association was detected between individual PTPN12 tag SNPs and GD but preliminary evidence suggests PTPN12 confers an increased risk of mild/moderate ophthalmopathy (NOSPECS classes 2-4) and that PTPN12 interacts with the TSHR. PMID: 17608818

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  • 亚细胞定位：
    Cytoplasm. Cell junction, focal adhesion. Cell projection, podosome.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Non-receptor class 4 subfamily
  • 数据库链接：

    HGNC: 9645

    OMIM: 600079

    KEGG: hsa:5782

    STRING: 9606.ENSP00000248594

    UniGene: Hs.61812