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PTPN13 Antibody

  • 货号：
    CSB-PA614263LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA614263LA01HU diluted at 1:300 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA614263LA01HU diluted at 1:300 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of A549 cells with CSB-PA614263LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PTPN13 Polyclonal antibody
  • Uniprot No.：
    Q12923
  • 基因名：
  • 别名：
    PTPN13 antibody; PNP1 antibody; PTP1E antibody; PTPL1 antibody; Tyrosine-protein phosphatase non-receptor type 13 antibody; EC 3.1.3.48 antibody; Fas-associated protein-tyrosine phosphatase 1 antibody; FAP-1 antibody; PTP-BAS antibody; Protein-tyrosine phosphatase 1E antibody; PTP-E1 antibody; hPTPE1 antibody; Protein-tyrosine phosphatase PTPL1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Tyrosine-protein phosphatase non-receptor type 13 protein (1965-2173AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PTPN13 Antibody (CSB-PA614263LA01HU)，的标记方式是Non-conjugated。对于PTPN13 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA614263LB01HU PTPN13 Antibody, HRP conjugated ELISA
    FITC CSB-PA614263LC01HU PTPN13 Antibody, FITC conjugated
    Biotin CSB-PA614263LD01HU PTPN13 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling. May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2.
  • 基因功能参考文献：
    1. MicroRNA-30e-5p promotes cell growth by targeting PTPN13 and indicates poor survival and recurrence in lung adenocarcinoma. PMID: 28653805
    2. The single nucleotide polymorphism genotype of PTPN13 exon 39 was determined in DNA extracted from blood samples from 174 sporadic colorectal cancer patients and 176 healthy individuals. The risk of colorectal cancer was 2.087 times greater for patients with the GG genotype than for those with the TT genotype. PTPN13 rs989902 is significantly associated with the risk of colorectal cancer in the Polish population. PMID: 28504867
    3. suggest that CAFs, irrespective of identity, have low influence on the degree of tumor infiltration by inflammatory- and/or immune-cells. However, CAFFAP may exert immuno-adjuvant roles in NSCLC, and targeting CAFs should be cautiously considered PMID: 29415055
    4. we found that miR-26a confers epidermal growth factor receptor-targeted tyrosine kinase inhibitors resistance of non-small cell lung cancer cells by targeting and silencing PTPN13 PMID: 27285768
    5. Fap1 inhibition increased Fas sensitivity and decreased beta-catenin activity in human CD34+ CML cells PMID: 26984787
    6. the crystal structure of the PTP-Bas PDZ1 domain at 1.6 A resolution, is reported. PMID: 27544031
    7. PTPN13 overexpression significantly inhibited the progression of HCC cells. PMID: 26801674
    8. Mutation in PTPN13 gene is associated with gastric cancer peritoneal carcinomatosis. PMID: 26811494
    9. This work studied heat diffusion in the well-known PDZ-2 protein, and confirmed that this protein has two cognate allosteric pathways and that heat flows preferentially through these. PMID: 25933631
    10. Necl-4 serves as a novel regulator for contact inhibition of cell movement and proliferation cooperatively with the VEGF receptor and PTPN13 PMID: 25893857
    11. A PDZ-mediated interaction of PTPN13 and PTEN is described with possible relevance for tumor suppression. PMID: 25448478
    12. The effect of the viscogens sucrose, and glycerol on the kinetic response of a photoperturbed PTPN13 is investigated. PMID: 25494785
    13. A comprehensive molecular dynamics simulation study of the PDZ2 domain of human tyrosine phosphatase 1E in the ligand-bound and -free state, as well as the photoswitchable protein in the cis and trans states of the photoswitch PMID: 25365469
    14. Thus, our results suggest a previously unknown Stat3-PTPN13 molecular network controlling squamous cell lung carcinoma development PMID: 24191246
    15. Association of rs7014346 in POU5F1P1, rs989902 in PTPN13, and rs7003146 in TCF7L2 with variations in the risk of breast cancer in a Chinese Han population. PMID: 24338422
    16. HCV induced increased expression of miR200c can down modulate the expression of FAP1, a critical regulator of Src and MAP kinase pathway that play an important role in the production of fibrogenic growth factors and development of fibrosis. PMID: 23950995
    17. selective autophagic degradation of the phosphatase Fap-1 promotes Fas apoptosis. PMID: 24316673
    18. Low PTPN13 expression is associated with invasion and metastasis of lung squamous cell carcinoma. PMID: 23906871
    19. Fap1-dependent inactivation of Gsk3beta and consequent stabilization of betacatenin in these cells. Consistent with this, Bcr-abl(+) cells exhibited a Fap1-dependent increase in betacatenin activity. PMID: 23519466
    20. PTPL1 dephosphorylates p85beta, promoting its binding to FBXL2 and degradation. PMID: 23604317
    21. Studied the peptide binding induced dynamical changes at the side-chain level throughout the second PDZ domain of PTP1e, identifying as such the collection of residues involved in long-range communication. PMID: 23209399
    22. CD95 signal transduction was not affected by FAP-1 expression in A818-6 monolayer cells; we found a polarisation-induced co-localisation of CD95 and FAP-1. PMID: 22364882
    23. Data show that EphrinB1, a PTPN13 substrate, interacts with ErbB2, and Src kinase mediates EphrinB1 phosphorylation and subsequent MAP Kinase signaling. PMID: 22279592
    24. interaction between Tel and Tel-PdgfRbeta decreases Tel/Icsbp/Hdac3 binding to the PTPN13 cis element, resulting in increased transcription. PMID: 22262849
    25. The PTPL1 is an important mediator of central cellular processes such as proliferation and invasion. PMID: 22274591
    26. The Ret oncoprotein exerts opposing controls on Fap-1 and CD95, increasing Fap-1 expression and decreasing CD95 cell surface expression. PMID: 21741956
    27. REVIEW: the alterations in expression and the genetic and epigenetic arguments supporting an oncogenic or an anti-oncogenic impact of PTPL1 PMID: 21235435
    28. X-ray crystal structures of PDZ2 in the absence and presence of RA-GEF2 ligand; very minor structural changes in PDZ2 accompany peptide binding PMID: 20839809
    29. FAP-1 was demonstrated to be responsible for the reduced sensitivity to CD95-mediated apoptosis in cells with inhibited miR-200. PMID: 20620960
    30. PTPL1 regulates breast cancer cell aggressiveness through direct inactivation of Src kinase. PMID: 20501847
    31. Transfection of FAP-1 siRNA into SW480 cells silenced the expression of FAP-1 and consequently abolished the inhibitory function of Fas/FasL-mediated apoptosis pathway, thus increasing the efficacy of chemotherapy for colon carcinoma with oxaliplatin. PMID: 20039457
    32. PTPN13 SNPs were found to influence susceptibility to a wide spectrum of cancers. PMID: 19672627
    33. Structure, dynamics and binding characteristics of the second PDZ domain of PTP-BL PMID: 11884147
    34. expression and apoptosis induction in peripheral blood cells from liver graft PMID: 11959286
    35. PDZ2 domain from cytosolic human phosphatase hPTP1E complexed with peptide, RA-GEF-2, reveals contribution of the beta2-beta3 loop to PDZ domain-ligand interactions PMID: 12095257
    36. PTPL1/FAP-1 has a key role in the apoptotic process in human breast cancer cells independent of Fas but associated with an early inhibition of the insulin receptor substrate-1/phosphatidylinositol 3-kinase pathway PMID: 12354757
    37. Shares a promoter region with the tightly linked gene encoding stress-activated protein kinase JNK3. PMID: 12436199
    38. FAP-1 has a role in binding to, and consequently inhibition of, Fas export to the cell surface PMID: 12724420
    39. specificity of interaction between the second PDZ domain of human protein tyrosine phosphatase1E (PDZ2) and a C-terminal peptide, ENEQVSAV, from the guanine nucleotide exchange factor RA-GEF-2 was investigated using FTIR spectroscopy and ESI-MS PMID: 12870871
    40. PTPL1 binds to tandem-PH-domain-containing protein (TAPP)-1. PMID: 14516276
    41. Data report the solution structure of the PDZ2 domain splicing variant of the protein tyrosine phosphatase PTP-Bas. PMID: 14596806
    42. X-ray crystallographic analysis of the PTPL1 catalytic domain PMID: 15611135
    43. We therefore report a novel transcriptional activation of a phosphatase involved in the oncogenesis of ESFT. PMID: 15782144
    44. FAP-1 expression is often up-regulated in metastatic tumors, with a causal connection withNF-kappaB-dependent transcriptional regulation of FAP-1 gene expression. PMID: 16306044
    45. FAP-1 could be inactivated during hepatocarcinogenesis, mainly attributed by allelic loss and promoter methylation. PMID: 16489062
    46. The PTPN13 protein has proapoptotic functions and can fuction as TSGs to suppress tumorigenesis. PMID: 16572203
    47. FAP-1 phosphatase activity could be responsible for NF-kappaB activation and resistance of SCCHN cells to Fas-mediated apoptosis. PMID: 16888780
    48. use the second PDZ domain (PDZ2) of protein tyrosine phosphatase (PTP1E) as a model to study the energetics of peptide binding to a class I PDZ domain. PMID: 17240990
    49. PTPN13/PTPL1 induces apoptosis through insulin receptor substrate-1 dephosphorylation PMID: 17638892
    50. cellular PTPN13 inhibits Her2 activity by dephosphorylating the signal domain of Her2 and plays a role in attenuating invasiveness and metastasis of Her2 overactive tumors. PMID: 17982484

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Nucleus. Cell projection, lamellipodium.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Non-receptor class subfamily
  • 组织特异性：
    Expressed in keratinocytes (at protein level). Present in most tissues with the exception of the liver and skeletal muscle. Most abundant in lung, kidney and fetal brain.
  • 数据库链接：

    HGNC: 9646

    OMIM: 600267

    KEGG: hsa:5783

    STRING: 9606.ENSP00000394794

    UniGene: Hs.436142