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PTPN18 Antibody

  • 中文名称：
    PTPN18兔多克隆抗体
  • 货号：
    CSB-PA858731ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: PTPN18 antibody IgG at 2.98μg/ml + Rat heart tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 51, 39 kDa
      Observed band size: 51 kDa
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA858731ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PTPN18 Polyclonal antibody
  • Uniprot No.：
    Q99952
  • 基因名：
    PTPN18
  • 别名：
    BDP 1 antibody; Brain derived phosphatase antibody; Brain-derived phosphatase antibody; Protein tyrosine phosphatase non receptor type 18 antibody; Protein tyrosine phosphatase non receptor type 18 brain derived antibody; PTN18_HUMAN antibody; PTP HSCF antibody; PTPN 18 antibody; PTPN18 antibody; Tyrosine protein phosphatase non receptor type 18 antibody; Tyrosine-protein phosphatase non-receptor type 18 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Rat
  • 免疫原：
    Recombinant Human Tyrosine-protein phosphatase non-receptor type 18 protein (1-210AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues.
  • 基因功能参考文献：
    1. PTPN12, PTPRN and PTPN18 were independent prognostic factors in Hepatocellular Carcinoma. PMID: 29742497
    2. PTPN18 regulates HER2-mediated cellular functions through defining both its phosphorylation and ubiquitination barcodes. PMID: 25081058
    3. BDP1 has a role in negative regulation of HER2 signaling PMID: 14660651
    4. novel isoform of PTPN18 based on analysis of expressed sequence tags was discovered; deletion of 4 exons in the catalytic domain of the isoform may alter enzymatic activity; 2 of the novel isoform predictions were experimentally validated through RT-PCR PMID: 16303740
  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Non-receptor class 4 subfamily
  • 组织特异性：
    Expressed in brain, colon and several tumor-derived cell lines.
  • 数据库链接：

    HGNC: 9649

    OMIM: 606587

    KEGG: hsa:26469

    STRING: 9606.ENSP00000175756

    UniGene: Hs.516390