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PTPN3 Antibody

  • 货号：
    CSB-PA019040LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA019040LA01HU diluted at 1:600 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA019040LA01HU diluted at 1:600 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of A549 cells with CSB-PA019040LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PTPN3 Polyclonal antibody
  • Uniprot No.：
    P26045
  • 基因名：
    PTPN3
  • 别名：
    cytoskeletal-associated protein tyrosine phosphatase antibody; protein tyrosine phosphatase H1 antibody; protein tyrosine phosphatase non-receptor type 3 antibody; Protein-tyrosine phosphatase H1 antibody; PTN3_HUMAN antibody; PTP-H1 antibody; PTPH1 antibody; PTPN3 antibody; Tyrosine-protein phosphatase non-receptor type 3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Tyrosine-protein phosphatase non-receptor type 3 protein (365-505AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PTPN3 Antibody (CSB-PA019040LA01HU)，的标记方式是Non-conjugated。对于PTPN3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA019040LB01HU PTPN3 Antibody, HRP conjugated ELISA
    FITC CSB-PA019040LC01HU PTPN3 Antibody, FITC conjugated
    Biotin CSB-PA019040LD01HU PTPN3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:500-1:1000
    IF 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.
  • 基因功能参考文献：
    1. High expression of PTPN3 was significantly associated with unfavorable prognosis of GBM. Moreover, in GBM cell lines, PTPN3 promoted cell proliferation and invasion, and the PTP common inhibitor pervanadate suppressed GBM proliferation and invasion. PMID: 30348936
    2. PTPN3 promotes tumorigenicity, stemness and drug resistance in ovarian cancer. PMID: 27833130
    3. Results indicate that protein tyrosine phosphatase non-receptor type 3 (PTPN3) may act as a tumor suppressor in lung cancer through its modulation of epidermal growth factor receptor (EGFR) signaling. PMID: 25263444
    4. analysis of how allosteric regulation of p38gamma and PTPN3 involves a PDZ domain-modulated complex formation PMID: 25314968
    5. These studies thus identified PTPH1 as a novel ER phosphatase and further demonstrate a therapeutic potential of enhancing breast cancer sensitivity to antiestrogens through dephosphorylating ER by PTPH1. PMID: 24227889
    6. Activating mutations in and high expression levels of PTPN3 were associated with tumor recurrence in cholangiocarcinoma. PMID: 24503127
    7. p38gamma Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response. PMID: 22730326
    8. The fusion transcript of ALK and PTPN3 identified resulted from translocation of a part of ALK gene into the third intron of PTPN3. Analysis of the transcript sequence indicates that no protein with any enzymatic activity is produced. PMID: 22334442
    9. PTPH1 stimulated breast cancer growth through regulating vitamin D receptor expression. PTPH1 was overexpressed in primary breast cancer and levels of its protein expression positively correlated with clinical metastasis. PMID: 21119599
    10. PTPH1 plays a role in Ras-dependent malignant growth by a mechanism depending on its p38gamma-binding activity. Ras increases p38gamma and PTPH1 expression and there is a coupling of increased p38gamma and PTPH1 protein expression in colon cancer. PMID: 20332238
    11. regulates TACE (tnf-alpha convertase} PMID: 12207026
    12. first reported demonstration that protein tyrosine phosphatase H1(PTPH1) is capable of interacting with and dephosphorylating T cell receptor zeta subunit PMID: 14672952
    13. PTPH1 binds to the PDZ-domain binding motif of the cardiac voltage-gated sodium channel Na(v)1 and regulates the activity of Na(v)1. PMID: 16930557
    14. Degradation of PTPN3 by HPV-16 E6 requires E6AP, the proteasome, and an interaction between the carboxy terminus of E6 and the PDZ domain of PTPN3. PMID: 17166906
    15. phosphatase activity and FERM domain of PTPN3 are essential for its suppression of HBV gene expression. PMID: 17588219
    16. PTP-H1 has a role in modulating GHR signaling and systemic growth through insulin-like growth factor 1 secretion PMID: 17921143
    17. Data suggest that reducing the level of PTPH1 may contribute to the oncogenic activity of high-risk genital E6 proteins. PMID: 17947517

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  • 亚细胞定位：
    Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Non-receptor class subfamily
  • 数据库链接：

    HGNC: 9655

    OMIM: 176877

    KEGG: hsa:5774

    STRING: 9606.ENSP00000363667

    UniGene: Hs.436429