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  4. PTPN9 Antibody

PTPN9 Antibody

  • 货号：
    CSB-PA019045LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA019045LA01HU diluted at 1:400 and staining in paraffin-embedded human appendix tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA019045LA01HU diluted at 1:400 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PTPN9 Polyclonal antibody
  • Uniprot No.：
    P43378
  • 基因名：
    PTPN9
  • 别名：
    MEG2 antibody; non-receptor type 9 antibody; protein tyrosine phosphatase antibody; Protein tyrosine phosphatase MEG2 antibody; Protein-tyrosine phosphatase MEG2 antibody; PTN9_HUMAN antibody; PTPase MEG2 antibody; Ptpn9 antibody; Tyrosine protein phosphatase non receptor type 9 antibody; Tyrosine-protein phosphatase non-receptor type 9 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Tyrosine-protein phosphatase non-receptor type 9 protein (221-339AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PTPN9 Antibody (CSB-PA019045LA01HU)，的标记方式是Non-conjugated。对于PTPN9 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA019045LB01HU PTPN9 Antibody, HRP conjugated ELISA
    FITC CSB-PA019045LC01HU PTPN9 Antibody, FITC conjugated
    Biotin CSB-PA019045LD01HU PTPN9 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus.
  • 基因功能参考文献：
    1. Results from a study on gene expression variability markers in early-stage human embryos shows that PTPN9 is a putative expression variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
    2. this study highlights an important role for miR-96 in the regulation of PTPN9 in breast cancer cells and may provide insight into the molecular mechanisms of breast carcinogenesis. PMID: 27857177
    3. Expression of MEG2 is reversely correlated with that of miR-181a-5p in gastric cancer. PMID: 28747184
    4. PTPN9 inhibited cell proliferation in HepG2 cells. PMID: 26715439
    5. PTPMeg2 is an important phosphatase for the dephosphorylation of STAT3 and plays a critical role in breast cancer development. PMID: 22394684
    6. This study indentified VEGFR2 as a PTPN9 substrate, and indicated that PTPN9 is a negative regulator of VEGFR2 signaling and function in endothelial cells. PMID: 22763125
    7. data suggest PTPN9 as a negative regulator of breast cancer cells by targeting ErbB2 and EGFR and inhibiting STAT activation PMID: 20335174
    8. Purification and characterization of protein tyrosine phosphatase PTP-MEG2 PMID: 12112018
    9. PTP-MEG2 has an important role in the development of erythroid cells. PMID: 12920026
    10. PTPase-MEG2 through its Sec14p homology domain couples inositide phosphorylation to tyrosine dephosphorylation and the regulation of intracellular traffic of the secretory pathway in T cells. PMID: 14662869
    11. PTP-MEG2 reduced the phosphotyrosine content of NSF and co-localized with NSF and syntaxin 6 in intact cells, the first demonstrated role for a protein tyrosine phosphatase in the regulated secretory pathway PMID: 15322554
    12. role in the negative regulation of hepatic insulin signaling PMID: 16679294
    13. the N terminus of PTPMEG2 is necessary for the targeting of this phosphatase to the secretory vesicle compartment by association with other proteins involved in intracellular transport. PMID: 17387180

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Non-receptor class 3 subfamily
  • 数据库链接：

    HGNC: 9661

    OMIM: 600768

    KEGG: hsa:5780

    STRING: 9606.ENSP00000303554

    UniGene: Hs.445775