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PTPRF Antibody

  • 货号：
    CSB-PA019053LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA019053LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA019053LA01HU at dilution of 1:100
    • Immunofluorescence staining of HepG2 cells with CSB-PA019053LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PTPRF Polyclonal antibody
  • Uniprot No.：
    P10586
  • 基因名：
  • 别名：
    FLJ43335 antibody; FLJ45062 antibody; FLJ45567 antibody; LAR antibody; LAR protein antibody; LARFN5C antibody; LARS antibody; LCA homolog antibody; Leukocyte antigen related (LAR) PTP receptor antibody; Leukocyte antigen related antibody; Leukocyte antigen related PTP receptor antibody; Leukocyte antigen related tyrosine phosphatase antibody; Leukocyte common antigen related antibody; Protein Tyrosine Phosphatase Receptor Type F antibody; Protein tyrosine phosphatase receptor type F polypeptide antibody; Ptprf antibody; PTPRF protein antibody; PTPRF_HUMAN antibody; Receptor linked protein tyrosine phosphatase LAR antibody; Receptor type tyrosine protein phosphatase F antibody; Receptor type tyrosine protein phosphatase F precursor antibody; Receptor-type tyrosine-protein phosphatase F antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Receptor-type tyrosine-protein phosphatase F protein (688-970AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PTPRF Antibody (CSB-PA019053LA01HU)，的标记方式是Non-conjugated。对于PTPRF Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA019053LB01HU PTPRF Antibody, HRP conjugated ELISA
    FITC CSB-PA019053LC01HU PTPRF Antibody, FITC conjugated
    Biotin CSB-PA019053LD01HU PTPRF Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity.; The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.
  • 基因功能参考文献：
    1. transferred nuclear Overhauser effects (trNOEs) have been employed in the docking program HADDOCK to generate models for the LAR-fondaparinux complex. These models are further analyzed by postprocessing energetic analysis to identify key binding interactions. PMID: 29570275
    2. PTPRF may have value as a predictive marker to identify which patients can obtain the greatest benefit from erlotinib in the post-first-line setting. PMID: 26291013
    3. Homozygous truncating PTPRF mutation causes athelia. PMID: 24781087
    4. PTPRF is down-regulated in hepatocellular carcinoma-facilitated tumor development. PMID: 24470239
    5. Interaction between the tripartite NGL-1, netrin-G1 and LAR adhesion complex promotes development of excitatory synapses. PMID: 23986473
    6. LAR functions as a negative regulator of adipogenesis. PMID: 19910497
    7. regulation of expression by cell density through functional E-cadherin complexes PMID: 12095414
    8. LAR PTPase domains play distinct functional roles in phosphorylation and dephosphorylation PMID: 12496362
    9. LAR as a crucial regulator of the sensitivity of two key insulin signalling pathways to insulin PMID: 15896785
    10. Results identify a protein tyrosine phosphatase as a potential substrate of TACE and describe proteolytic processing of PTP-LAR as a means of regulating phosphatase activity downstream and thus under the control of EGFR-mediated signaling pathways. PMID: 16478662
    11. Regulated degradation of liprinalpha1 is important for proper LAR receptor distribution, and could provide a mechanism for localized control of dendrite and synapse morphogenesis by activity and CaMKII. PMID: 17419996
    12. LAR and Src are identified as Death-associated protein kinase (DAPK) regulators through their reciprocal modification of DAPK Y491/492 residues and establishes a functional link of this DAPK-regulatory circuit to tumor progression. PMID: 17803936

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  • 相关疾病：
    Aplasia or hypoplasia of the breasts and/or nipples 2 (BNAH2)
  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Receptor class 2A subfamily
  • 数据库链接：

    HGNC: 9670

    OMIM: 179590

    KEGG: hsa:5792

    STRING: 9606.ENSP00000353030

    UniGene: Hs.272062