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PTPRK Antibody

  • 货号：
    CSB-PA613588LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA613588LA01HU diluted at 1:400 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA613588LA01HU diluted at 1:400 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of HepG2 cells with CSB-PA613588LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PTPRK Polyclonal antibody
  • Uniprot No.：
    Q15262
  • 基因名：
    PTPRK
  • 别名：
    dJ480J14.2.1 antibody; DKFZp686C2268 antibody; DKFZp779N1045 antibody; OTTHUMP00000017180 antibody; OTTHUMP00000017181 antibody; OTTHUMP00000017182 antibody; OTTHUMP00000017187 antibody; OTTHUMP00000040306 antibody; Protein tyrosine phosphatase kappa antibody; Protein tyrosine phosphatase kappa precursor antibody; Protein tyrosine phosphatase receptor type K antibody; Protein tyrosine phosphatase receptor type kappa antibody; Protein-tyrosine phosphatase kappa antibody; PTPK antibody; PTPkappa antibody; Ptprk antibody; PTPRK_HUMAN antibody; R PTP kappa antibody; R-PTP-kappa antibody; Receptor type tyrosine protein phosphatase kappa antibody; Receptor-type tyrosine-protein phosphatase kappa antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Receptor-type tyrosine-protein phosphatase kappa protein (589-749AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PTPRK Antibody (CSB-PA613588LA01HU)，的标记方式是Non-conjugated。对于PTPRK Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA613588LB01HU PTPRK Antibody, HRP conjugated ELISA
    FITC CSB-PA613588LC01HU PTPRK Antibody, FITC conjugated
    Biotin CSB-PA613588LD01HU PTPRK Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa.
  • 基因功能参考文献：
    1. PTPRK was identified as a direct target of miR-1260b, and PTPRK expression was inversely correlated with miR-1260b in non-small cell lung cancer cell lines and clinical tissues PMID: 29628123
    2. Study found a significant association between PTPRK genetic variants and the risk and age at onset of Alzheimer's disease in two independent samples, and provided initial evidence of several genetic variants in PTPRK influencing the risk of cancer and cholesterol levels. PMID: 28987514
    3. The present study identified RSPO fusion transcripts, including three novel transcripts, in one-third of colorectal Traditional serrated adenoma (TSA) and showed that PTPRK-RSPO3 fusions were the predominant cause of RSPO overexpression in colorectal TSA. PMID: 28543708
    4. PTPRK plays dual roles in coordinating angiogenesis. It plays a positive role in cell proliferation, adhesion and tubule formation, but suppresses cell migration, in particular, the FGF-promoted migration. PMID: 28259897
    5. PTPRK-RSPO3 fusions and RNF43 mutations were found to be characteristic genetic features of traditional serrated adenomas (TSAs). PMID: 26924569
    6. By regulating phosphorylation of SRC, RPTPkappa promotes the pathogenic action of rheumatoid arthritis fibroblast-like synoviocytes, mediating cross-activation of growth factor and inflammatory cytokine signalling by TGFbeta in RA FLS. PMID: 25378349
    7. Notch and TGF-beta act in concert to stimulate induction of PTPRK, which suppresses EGFR activation in human keratinocytes. PMID: 25609089
    8. Findings strongly indicate that the tyrosine phosphorylation of CD133, which is dephosphorylated by PTPRK, regulates AKT signaling and has a critical role in colon cancer progression. PMID: 24882578
    9. PTPRK underexpression leads to STAT3 activation and contributes to nasal NK/T-cell lymphoma pathogenesis PMID: 25612622
    10. PTPRK showed lower mRNA expression in duodenal mucose of celiac disease patients. PMID: 23820479
    11. High expression of PTPRK is associated with prostate cancer. PMID: 24002526
    12. Tumor derived mutations of protein tyrosine phosphatase receptor type k affect its function and alter sensitivity to chemotherapeutics in glioma. PMID: 23696788
    13. PTPRK is a negative regulator of adhesion, invasion, migration, and proliferation of breast cancer cells. PMID: 23552869
    14. PTPkappa was scissored by the processed form of proprotein convertase 5, and galectin-3 binding protein which is over-produced in colon cancer cells and tissues. PMID: 21094132
    15. These data describe a novel mechanism of cross-talk between EGFR and TGF-beta pathways, in which RPTP-kappa functions to integrate growth-promoting and growth-inhibiting signaling pathways. PMID: 19864455
    16. Our results suggest that GnT-V could decrease human hepatoma SMMC-7721 cell adhesion and promote cell proliferation partially through RPTPkappa. PMID: 19911372
    17. RPTP-kappa is a key regulator of EGFR tyrosine phosphorylation and function in human keratinocytes PMID: 16263724
    18. the crystal structure of catalytically active, monomeric D1 domain of RPTPkappa at 1.9 A. RPTPkappa is monomeric in solution and crystal structure. PMID: 16672235
    19. EGF receptor is activated in human keratinocytes by oxidative inhibition of receptor-type protein-tyrosine phosphatase kappa by ultraviolet irradiation PMID: 16849327
    20. EBNA1 apparently disables TGF-beta signaling, which subsequently decreases transcription of the PTPRK tumor suppressor PMID: 17720884
    21. PTPRK influences transactivating activity of beta-catenin in non-tumoral and neoplastic cells by regulating the balance between signaling and adhesive beta-catenin, thus providing biochemical basis for the hypothesis of PTPRK as a tumor suppressor gene. PMID: 18276111
    22. overexpression of GnT-V in a hepatoma cell line not only induced the addition of beta1,6 GlcNAc branch to N-glycan of RPTPkappa but also decreased the protein level of RPTPkappa PMID: 19236842
    23. These data indicate that PPTRK positively regulates ERK1/2 phosphorylation, which impacts CD4(+) T cell development. PMID: 19800317

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  • 亚细胞定位：
    Cell junction, adherens junction. Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Receptor class 2B subfamily
  • 组织特异性：
    High levels in lung, brain and colon; less in liver, pancreas, stomach, kidney, placenta and mammary carcinoma.
  • 数据库链接：

    HGNC: 9674

    OMIM: 602545

    KEGG: hsa:5796

    STRING: 9606.ENSP00000357196

    UniGene: Hs.155919