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PXK Antibody

  • 货号：
    CSB-PA770363LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: HEK293 whole cell lysate, A549 whole cell lysate, Mouse brain tissue, Mouse heart tissue, Rat brain tissue
      All lanes: PXK antibody at 2.7µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 65, 59, 39, 63, 50, 61, 56 kDa
      Observed band size: 65 kDa
    • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA770363LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA770363LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PXK Polyclonal antibody
  • Uniprot No.：
    Q7Z7A4
  • 基因名：
    PXK
  • 别名：
    FLJ20335 antibody; K-ATPase antibody; Modulator of Na antibody; Modulator of Na K ATPase antibody; Modulator of Na K ATPase long form antibody; MONaKA antibody; PX domain containing protein kinase like protein antibody; PX domain containing serine/threonine kinase antibody; PX domain-containing protein kinase-like protein antibody; PX ser/thr kinase v2 antibody; PX serine/threonine kinase antibody; Pxk antibody; PXK_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human PX domain-containing protein kinase-like protein (1-200AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PXK Antibody (CSB-PA770363LA01HU)，的标记方式是Non-conjugated。对于PXK Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA770363LB01HU PXK Antibody, HRP conjugated ELISA
    FITC CSB-PA770363LC01HU PXK Antibody, FITC conjugated
    Biotin CSB-PA770363LD01HU PXK Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity.
  • 基因功能参考文献：
    1. First described as part of human kinome analysis, named Slob after Drosophila ortholog. PMID: 15289607
    2. Two of these kinases that were classified as resistors were PX domain-containing serine/threonine kinase (PXK) and AP2-associated kinase 1 (AAK1), which promote receptor endocytosis and may enable cells to resist TRAIL-induced apoptosis PMID: 25852190
    3. genetic association study in Han population in China: Data suggest an SNP in PXK [rs2176082(C/T); but not rs6445975(G/T)] is associated with recurrent pregnancy loss; SNPs in KIAA0319L [rs2275247(A/G)] or JAZF1 [rs1635852(C/T)] are not associated. PMID: 25596907
    4. Results confirm the genetic association of the locus 3p14.3 with systemic lupus erythematosus in Europeans and point to the ABHD6 and not PXK, as the major susceptibility gene in the region. PMID: 24534757
    5. study determined that the previously described systemic lupus erythematosus susceptibility loci PXK (P = 3.27 x 10(-11), OR = 1.20) and JAZF1 (P = 1.11 x 10(-8), OR = 1.13) are shared with systemic sclerosis PMID: 23740937
    6. The rs6445975 polymorphism of PXK and the rs2304256 polymorphism of tyrosine kinase 2 are associated with the development of systemic lupus erythematosus in Europeans PMID: 22592861
    7. The association of PXK rs6445975 with systemic lupus erythematosus that was previously observed in Caucasians was not replicated in Koreans or in Hong Kong Chinese. PMID: 21243490
    8. These results indicate that PXK plays a critical role in epidermal growth factor receptor trafficking through modulating ligand-induced ubiquitination of the receptor. PMID: 20086096
    9. MONaKA modulates brain Na,K-ATPase by binding tightly to its beta1 and beta3 subunits, and may thereby participate in the regulation of electrical excitability and synaptic transmission [MONaKA] PMID: 16135750
    10. study presents four new regions having genetic associations with systemic lupus erythematosus in women of European descent: ITGAM, KIAA1542, PXK and rs10798269 PMID: 18204446

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  • 亚细胞定位：
    Cytoplasm. Cell membrane; Peripheral membrane protein. Note=Also associates with the plasma membrane. Isoform 3 is present throughout the cell.
  • 蛋白家族：
    Protein kinase superfamily
  • 组织特异性：
    Widely expressed in all tissues examined except in heart. Isoform 1 is expressed in high levels in the brain, skeletal muscle, spleen and testis. Isoform 7 expression has yet to be demonstrated.
  • 数据库链接：

    HGNC: 23326

    OMIM: 611450

    KEGG: hsa:54899

    STRING: 9606.ENSP00000348472

    UniGene: Hs.190544