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PYCR2 Antibody

  • 货号：
    CSB-PA019116GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q96C36
  • 基因名：
    PYCR2
  • 别名：
    1810018M05Rik antibody; FLJ54750 antibody; Leftb antibody; OTTHUMP00000035614 antibody; P5C reductase 2 antibody; P5CR 2 antibody; P5CR2 antibody; P5CR2_HUMAN antibody; PYCR 2 antibody; PYCR2 antibody; Pyrroline 5 carboxylate reductase 2 antibody; Pyrroline 5 carboxylate reductase family member 2 antibody; Pyrroline 5 carboxylate reductase isoform antibody; Pyrroline-5-carboxylate reductase 2 antibody; RP4-559A3.4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Human PYCR2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    0.1M NaHCO3,0.1M Glycine, 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH. Involved in cellular response to oxidative stress.
  • 基因功能参考文献：
    1. PYCR2-related syndrome represents a clinically recognizable condition in which PYCR2 mutations lead to protein dysfunction. PMID: 27130255
    2. It was found that silence of PYCR2 resulted in the decrease of proliferative ability and activation of AMPK/mTOR-induced autophagy of A375 cells. PYCR2 silencing also activated AMPK/mTOR pathway in another melanoma cell line, CHL-1. PMID: 26634742
    3. Silencing of both PYCR1 and PYCR2 completely abolished anti-oxidation activity of RRM2B, demonstrating a functional collaboration of these metabolic enzymes in response to oxidative stress. PMID: 26733354
    4. Hypomyelination and the absence of lax caused by previously reported mutations in the gene encoding PYCR2's isozyme, PYCR1, suggesting a unique and indispensable role for PYCR2 in the human CNS during development. PMID: 25865492
  • 相关疾病：
    Leukodystrophy, hypomyelinating, 10 (HLD10)
  • 亚细胞定位：
    Cytoplasm. Mitochondrion.
  • 蛋白家族：
    Pyrroline-5-carboxylate reductase family
  • 组织特异性：
    Detected in erythrocytes (at protein level). Expressed in fetal brain.
  • 数据库链接：

    HGNC: 30262

    OMIM: 616406

    KEGG: hsa:29920

    STRING: 9606.ENSP00000342502

    UniGene: Hs.654718