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Paox Antibody

  • 货号：
    CSB-PA804896LA01MO
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Mus musculus (Mouse) Paox Polyclonal antibody
  • Uniprot No.：
    Q8C0L6
  • 基因名：
    Paox
  • 别名：
    Paox antibody; Pao antibody; Peroxisomal N(1)-acetyl-spermine/spermidine oxidase antibody; EC 1.5.3.13 antibody; Polyamine oxidase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Mouse
  • 免疫原：
    Recombinant Mouse Peroxisomal N(1)-acetyl-spermine/spermidine oxidase protein (1-504AA)
  • 免疫原种属：
    Mus musculus (Mouse)
  • 标记方式：
    Non-conjugated

    本页面中的产品，Paox Antibody (CSB-PA804896LA01MO)，的标记方式是Non-conjugated。对于Paox Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA804896LB01MO Paox Antibody, HRP conjugated ELISA
    FITC CSB-PA804896LC01MO Paox Antibody, FITC conjugated
    Biotin CSB-PA804896LD01MO Paox Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs.
  • 基因功能参考文献：
    1. Steady-state kinetics of His64 mutant proteins shows that the mutations result in a decrease of ~15-fold in the rate constant for amine oxidation. PMID: 22959971
    2. N,N'-dibenzyl-1,4-diaminobutanes, with only two nitrogens, are also substrates of polyamine oxidase. PMID: 19911805
    3. translated amino acid sequences of mpao and bpao have a -Pro-Arg-Leu peroxisomal targeting signal at the extreme C termini and a beta-alpha-beta FAD-binding motif is present in the N-terminal portion of mPAO. PMID: 12660232
    4. new mechanism for pathogen-induced oxidative stress in macrophages in which activation of PAO1 leads to H(2)O(2) release and apoptosis by a mitochondrial-dependent cell death pathway PMID: 15247269
  • 亚细胞定位：
    Peroxisome. Cytoplasm.
  • 蛋白家族：
    Flavin monoamine oxidase family
  • 组织特异性：
    Widely expressed at different developmental stages. Expressed at high level in the liver and the stomach, expressed at lower level in heart, spleen, thymus, small intestine, muscle, pancreas, uterus, and breast and expressed at very low level in brain, ki
  • 数据库链接：

    KEGG: mmu:212503

    STRING: 10090.ENSMUSP00000026537

    UniGene: Mm.486735