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Phospho-APLP2 (Tyr755) Antibody

  • 货号：
    CSB-PA254734
  • 规格：
    ￥2454
  • 图片：
    • Immunohistochemical analysis of paraffin-embedded human brain tissue using APLP2 (Phospho-Tyr755) antibody (left)or the same antibody preincubated with blocking peptide (right).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) APLP2 Polyclonal antibody
  • Uniprot No.：
    Q06481
  • 基因名：
    APLP2
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Peptide sequence around phosphorylation site of tyrosine 755 (P-T-Y(p)-K-Y) derived from Human APLP2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:50-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts.
  • 基因功能参考文献：
    1. the expression of APLP2 might correlate with tumor development and be a prognostic factor for patients with glioblastoma PMID: 29663738
    2. These findings suggest that the identified APLP2, RRM2, and PRC1 signature could be useful for distinguishing between benign (follicular adenoma) and malignant (follicular carcionma and follicular variant of papillary carcinoma) tumors of the thyroid follicular epithelium. PMID: 27796194
    3. This paper demonstrates an important role for APLP2 in refractive development in mice and humans, suggesting a high level of evolutionary conservation of the signaling pathways underlying refractive eye development. PMID: 26313004
    4. Data show that amyloid precursor-like protein 2 (APLP2) expression is elevated in pancreatic cancer metastases. PMID: 25576918
    5. We conclude that PCSK9 enhances the degradation of the LDLR independently of either APLP2 or sortilin both ex vivo and in mice. PMID: 26085104
    6. our discoveries establish a role for APLP2 in the growth of pancreatic cancer cells and show that inhibitors preventing APLP2 cleavage reduce the viability of pancreatic cancer cells. PMID: 22797723
    7. amyloid precursor protein-like protein-2, but not amyloid precursor protein, is involved in mediating postendocytic delivery of PCSK9 to lysosomes and is therefore important for PCSK9 function PMID: 23430252
    8. Aberrant enhancement of YWK-II/APLP2 by nuclear export of Bat3 may play a role in cancer development by inhibiting cell apoptosis. PMID: 22641691
    9. APP and its mammalian homologs, amyloid precursor-like proteins APLP1 and APLP2, participate under physiological conditions via trans-cellular dimerization in synaptogenesis. PMID: 21952790
    10. APLP-2 (and APLP1) are capable of activating gene transcription via binding to Mint3. PMID: 21178287
    11. Regulation of major histocompatibility complex class I molecule expression on cancer cells by amyloid precursor-like protein 2. PMID: 21826533
    12. The interaction between APLP2 and ataxin-7 and proteolytic processing of APLP2 may contribute to the pathogenesis of spinocerebellar ataxia type 7. PMID: 20732423
    13. APLP1 and APLP2 are processed by the gamma-secretase in a Presenilin 1-dependent manner and the extreme carboxyl-terminal fragments produced by this processing (APP-like Intracellular Domain are able to enhance Fe65-dependent gene activation PMID: 12228233
    14. crystals of extracellular fragment X3 of a human sperm membrane protein YWK-II/APPH have been grow by the vapour-diffusion method [YWK-II PROTEIN] PMID: 12595709
    15. Sustained levels of APP and the elevated levels of APLP2, in spite of the reduced mRNA expression, are due to altered proteolytic processing of these proteins. PMID: 14597230
    16. The APLP2 gene has no CAGA box, but it does have a GAGA sequence in a location similar to that of the CAGA box in the APP gene. PMID: 15208260
    17. Interaction of human and murine Abeta peptides, Abeta40 and Abeta42. Interspecies Abeta aggregates and fibres are readily formed and are more stable than homogenous human fibres. (Amyloid beta 40 and 42) PMID: 15584916
    18. APLP2 is shed by disintegrins and metalloproteinases. Overexpression of secretase or TACE in HEK293 cells increases the release of neurotrophic soluble APLP2 severalfold. PMID: 16279945
    19. findings show an increase in the immunoreactivities for the nuclear C-terminal fragments of APLP2 and for GSK-3beta in the brains of Alzheimer disease patients PMID: 16645641
    20. APLP2 and APP have roles in sperm function PMID: 17405931
    21. YWK-II (APLP2 protein) is a G(o)-coupled receptor for Mullerian inhibiting substance in mediating ERK1/2 activation leading to anti-apoptotic activity or cell survival. PMID: 17452623
    22. APLP2/MHC association is influenced by multiple domains of the MHC class I heavy chain and by beta(2)m's effects on the conformation of the heavy chain. PMID: 18452037
    23. APLP2 modulates the stability and endocytosis of K(d) molecules PMID: 18641335
    24. APLP2 has a multistep trafficking function that influences the expression of major histocompatibility complex class I molecules at the plasma membrane PMID: 19808674

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Nucleus.
  • 蛋白家族：
    APP family
  • 组织特异性：
    Expressed in placenta, brain, heart, lung, liver, kidney and endothelial tissues.
  • 数据库链接：

    HGNC: 598

    OMIM: 104776

    KEGG: hsa:334

    STRING: 9606.ENSP00000263574

    UniGene: Hs.370247