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  4. Phospho-AURKC (Thr236/202) Antibody

Phospho-AURKC (Thr236/202) Antibody

  • 货号：
    CSB-PA238732
  • 规格：
    ￥2454
  • 图片：
    • Immunohistochemistry analysis of paraffin-embedded human brain tissue using AurB/C (Phospho-Thr236/202) antibody. The picture on the right is treated with the synthesized peptide.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) AURKC Polyclonal antibody
  • Uniprot No.：
    Q9UQB9
  • 基因名：
    AURKC
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Peptide sequence around phosphorylation site of threonine 236/202 (C-G-T(p)-L-D) derived from Human AurB/C.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:50-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.
  • 基因功能参考文献：
    1. Teratozoospermia is not correlated with c.144delC mutation in the AURKC gene in the men of the Sichuan area. Therefore, large-scale genotyping of the AURKC gene may not be necessary clinically among Chinese patients with idiopathic teratozoospermia. PMID: 29738175
    2. The epigenetic targets AURKB, AURKC and DNMT3B, and the global DNA methylation profile are regulated during HIV-1 replication in CD4+ T cells, and this regulation can be influenced by the activation state of the cell at the time of infection. PMID: 30077875
    3. Two novel DMRs, located in RPS6KA4/MIR1237 and the AURKC promoter, were found to be hypermethylated in WT PMID: 28930610
    4. Identification and characterization of AURKB and AURKC variants associated with maternal aneuploidy has been reported. PMID: 28369513
    5. Aurora-C interactions with members of the Chromosome Passenger Complex (CPC), Survivin and Inner Centromere Protein (INCENP) in reference to known Aurora-B interactions to understand the functional significance of Aurora-C overexpression in human cancer cells, is reported. PMID: 27332895
    6. Patients presenting with a monomorphic teratozoospermia such as globozoospermia or macrospermia with more than 85% of the spermatozoa presenting this specific abnormality have been analyzed permitting to identify several key genes for spermatogenesis such as AURKC and DPY19L2. PMID: 27779748
    7. Homozygous c.144delC mutation in AURKC gene in infertile men with macrozoospermia in the Tunisian population PMID: 26341096
    8. AURKC mutations are more frequent than Klinefelter syndrome and constitute the leading genetic cause of infertility in North African men. PMID: 25219909
    9. Low AURKC expression is associated with cancer. PMID: 25990457
    10. Overexpression of AURKC is associated with breast tumors. PMID: 25994570
    11. may play an important role in the development of colorectal cancer PMID: 26118178
    12. Aberrantly expressed Aurora-C in somatic cancer cells may impair spindle checkpoint assembly by displacing the centromeric localization of chromosomal passenger complexes. PMID: 24603334
    13. Our data indicate that the AURKC c.144delC mutation has a relatively high carrier frequency in the Moroccan population. PMID: 24484996
    14. expression of AURKC, OIP5, PIWIL2 and TAF7L differed between patients with Acute myeloid leukemia, myelodysplastic syndrome and healthy controls in a gender-dependent manner PMID: 23292864
    15. Here we provide evidence for the first time of Aurora-C overexpression and gene amplification. PMID: 23581231
    16. Investigators identified a new non-sense mutation in aurora kinase C, p.Y248*, in 10 unrelated individuals of European and North African origin; this mutation is associated with macrozoospermia and male infertility. PMID: 22888167
    17. Molecular analysis of the AURKC gene was carried out in two brothers presenting with a typical large-headed spermatozoa phenotype. Both affected brothers were heterozygous for the c.144delC mutation in the AURKC gene. PMID: 21733974
    18. Aurora C mRNA is up-regulated with Aurora B after activation of the embryonic genome and both proteins were detected in early Day 4 embryos. PMID: 21493633
    19. we show that elevated AURKC increases the proliferation, transformation and migration of cancer cells PMID: 21710690
    20. Overexpressed Aurora-C (AURKC) is an oncogene. Overexpression of Aurora-C induces abnormal cell division resulting in centrosome amplification and multinucleation. Cells overexpressing active Aurora-C induced tumour formation in nude mice. PMID: 22046298
    21. We confirm in this study the research interest of the recurrent mutation c.144delC in the gene AURKC in male infertility with high rates of large-headed spermatozoa PMID: 21353399
    22. the study demonstrated that TACC1 localizes at the midbody during cytokinesis and interacts with and is a substrate of Aurora-C, which warrant further investigation in order to elucidate the functional significance of this interaction. PMID: 21531210
    23. Aurora-C mRNA was reduced to 0.20 +/- 0.32 fold (P < 0.01) in 13 seminomas and up-regulated in one case PMID: 20629650
    24. association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C PMID: 15316025
    25. Aurora-C interacts with the inner centromere protein (INCENP) at the carboxyl terminal end spanning the conserved IN box domain. PMID: 15499654
    26. Therefore, we speculated that Aurora C-SV might also contribute to the regulation of chromosome segregation and cytokinesis. PMID: 15670791
    27. Aurora-C is a chromosomal passenger protein that disrupts the association of INCENP with Aurora-B and may serve as a key regulator in cell division PMID: 15917996
    28. Aurora-c is directly associated with surwvivin and is required for cytokinesis. PMID: 15938719
    29. A role of Aurora-C in the development and progression of cancer especially in the presence of mutated p53. PMID: 16258285
    30. Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility. PMID: 17435757
    31. Results demonstrate that human Auroras a regulator of cell morphology and cell growth, and that the non-conserved T191 in the activation loop of Auroras of major importance for its regulation. PMID: 17637569
    32. Aurora C phosphorylates TRF2 PMID: 18309533
    33. A functional AURKC protein is necessary for male meiotic cytokinesis while its absence does not impair oogenesis. PMID: 19147683
    34. Aurora-C can perform the same essential functions as Aurora-B in mitosis: regulation of kinetochore-microtubule attachments, the spindle assembly checkpoint, and cytokinesis PMID: 19713763

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  • 相关疾病：
    Spermatogenic failure 5 (SPGF5)
  • 亚细胞定位：
    Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle.
  • 蛋白家族：
    Protein kinase superfamily, Ser/Thr protein kinase family, Aurora subfamily
  • 组织特异性：
    Isoform 1 and isoform 2 are expressed in testis. Elevated expression levels were seen only in a subset of cancer cell lines such as Hep-G2, Huh-7 and HeLa. Expression is maximum at M phase.
  • 数据库链接：

    HGNC: 11391

    OMIM: 243060

    KEGG: hsa:6795

    STRING: 9606.ENSP00000302898

    UniGene: Hs.98338