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Phospho-BMX (Tyr566) Antibody

  • 货号：
    CSB-PA993762
  • 规格：
    ￥2454
  • 图片：
    • Western blot analysis of extracts from HeLa cells treated with Serum using Phospho-ETK (Tyr566) antibody.The lane on the right is treated with the antigen-specific peptide.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) BMX Polyclonal antibody
  • Uniprot No.：
    P51813
  • 基因名：
    BMX
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Peptide sequence around phosphorylation site of Tyrosine566 (D-Q-Y(p)-V-S) derived from Human ETK.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells.
  • 基因功能参考文献：
    1. These results suggested that BMX can promote cell proliferation through PI3K/AKT/mTOR and STAT3 signaling pathways in cervical cancer cells. PMID: 28514765
    2. The studies suggested that BMXDeltaN might play roles in lung tumorigenicity, with expression of BMXDeltaN promoting cell growth, cell migration, and cell transformation. PMID: 28422715
    3. results demonstrate that cleaved BMX is a novel N-end rule substrate, and its degradation exhibits a novel interplay between substrate phosphorylation and N-end rule degradation, revealing an increasing complex regulatory network of apoptotic proteolytic signaling cascades. PMID: 27601470
    4. Data indicate that EPHA3 is involved in regulating the multidrug resistance (MDR) of small cell lung cancer (SCLC) via PI3K/BMX/STAT3 signaling and may be a therapeutic target in SCLC. PMID: 27101199
    5. Report BMX-ARHGAP gene fusion in gastric cardia adenocarcinoma. PMID: 25499959
    6. These findings suggested that polymorphisms of the BMX gene could be a potential predictor of clinical symptoms following mTBI. PMID: 24860816
    7. BMX is an antiapoptotic downstream effector of PI3K, independent of AKT. PMID: 24709422
    8. The effects of dietary K(+) on Bmx were more pronounced PMID: 24785188
    9. Overexpression of ETK is associated with the malignancy and disease progression of renal cell carcinoma. PMID: 24606948
    10. This review characterizes the role of BMX in inflamamtion, cardiovascular disease and cancer. PMID: 22449076
    11. Etk/BMX may play a role in protection of NPC cells from apoptosis. PMID: 21339702
    12. study concludes that BMX is an essential component of inflammatory cytokine signaling and that catalytic, as well as noncatalytic functions of BMX are involved PMID: 21471444
    13. Deregulation of ETK may attribute to the elevated activity of STAT3 and AKT frequently detected in bladder cancer. PMID: 21408190
    14. BMX is associated with multi-drug resistance of K562/HHT cell line. PMID: 19951526
    15. Constitutively active STAT3 rescued the effects of BMX downregulation, supporting that BMX signals through STAT3 in glioblastoma stem cells (GSCs). PMID: 21481791
    16. possible role in regulation of vesicle trafficking PMID: 11877430
    17. Investigate Bmx mediates VEGF-dependent lymphangiogenic signaling. PMID: 20864667
    18. by preventing binding of Etk/Bmx to PAR(1) -C-tail, hPar1 oncogenic properties are abrogated PMID: 20559570
    19. high expression of Etk occurs in 74.6% of SCLC cases, but only in 40% of NSCLC cases, and there is marked difference in the expression levels of Bcl-2, Bcl-X(L) and p53 between Etk-positive and Etk-negative SCLC cases PMID: 20206622
    20. BMX/Etk is a TNFR2-specific kinase involved in TNF-induced angiogenic events PMID: 12370298
    21. Etk activation is essential for transducing the EGF-induced apoptotic signaling in breast cancer cells. PMID: 14676838
    22. Pim1 and Etk are required for IL6-induced activation of androgen receptor-mediated transcription in prostate cancer. PMID: 14981536
    23. Bmx is a downstream Rap1 effector in VEGF-induced endothelial cell activation. PMID: 15207703
    24. two isoforms of Pim-1 kinase may regulate distinct substrates and the 44 kDa Pim-1 may play a more prominent role in drug resistance in prostate cancer cells and interact directly with tyrosine kinase Etk/BMX PMID: 16186805
    25. Etk transgenic mouse model may be a useful tool for studying the functions of Etk and identification of new molecular markers and drug targets relevant to human diseases. PMID: 16912182
    26. Role of Bmx in ischemia-mediated arteriogenesis/angiogenesis: response to ischemia, enhanced in transgenic mice. PMID: 16932810
    27. results demonstrate that Bmx is a critical downstream target of the constitutively active PI 3-kinase in PTEN-deficient PCa cells and further show that Bmx is recruited by the EGF receptor and ErbB3 and activated in response to their respective ligands PMID: 17823122
    28. Mechanisms regulating IL-6 production led to the discovery that the Tec kinase bone marrow tyrosine kinase gene in chromosome X (Bmx) regulates Toll-like receptor 4-induced IL-6 production. PMID: 18025155
    29. Etk/Bmx may have different biological roles in tumor and nontumor cells, and may be involved in regulating hepatocyte differentiation by c-Fos activation in HCC. PMID: 18196928
    30. In fibroblast-like synoviocytes of rheumatoid arthritis patients, Etk is implicated in the cross-talk between focal adhesion kinase (FAK) and myeloid differentiation factor 88 (MyD88) pathways. PMID: 18292575
    31. Bmx kinase activity in fibroblasts from rheumatoid synovium is increased following LPS stimulation; Bmx is involved in the regulation of LPS-induced IL-6 and VEGF production via mRNA stabilisation. PMID: 18402776
    32. Pretreatment of umbilical vein cells with a pharmacologic inhibitor of Bmx, LFM-A13, produced significant radiosensitization of endothelial cells measured by clonogenic survival analysis and apoptosis. PMID: 18413754

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  • 亚细胞定位：
    Cytoplasm. Note=Localizes to the edges of spreading cells when complexed with BCAR1.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, TEC subfamily
  • 组织特异性：
    Highly expressed in cells with great migratory potential, including endothelial cells and metastatic carcinoma cell lines.
  • 数据库链接：

    HGNC: 1079

    OMIM: 300101

    KEGG: hsa:660

    STRING: 9606.ENSP00000308774

    UniGene: Hs.495731