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  4. Phospho-GRIA4 (S862) Antibody

Phospho-GRIA4 (S862) Antibody

  • 货号：
    CSB-PA008958
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    P48058
  • 基因名：
  • 别名：
    AMPA 4 antibody; AMPA selective glutamate receptor 4 antibody; AMPA-selective glutamate receptor 4 antibody; AMPA4 antibody; GluA 4 antibody; GluA4 antibody; GluR 4 antibody; GluR D antibody; GluR-4 antibody; GluR-D antibody; GluR4 antibody; GLUR4C antibody; GLURD antibody; Glutamate receptor 4 antibody; Glutamate receptor ionotrophic AMPA 4 antibody; Glutamate receptor ionotropic antibody; GRIA 4 antibody; Gria4 antibody; GRIA4_HUMAN antibody; Ionotropic Glutamate receptor 4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from Human GluR4 around the phosphorylation site of S862.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
  • 基因功能参考文献：
    1. The s suggest that pathogenic de novo variants in GRIA4 lead to intellectual disability with or without seizures, gait abnormalities, problems of social behavior, and other variable features. PMID: 29220673
    2. Study shows that alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit GluA4 is expressed on oligodendrocytes, myelin and on axons in humans. PMID: 27443784
    3. This study demonstrated that the GRIA4 protein was altered in auditory cortex patient with schizophreia. PMID: 25433904
    4. Interaction with the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit GluR4. PMID: 24962026
    5. Did not observed any significant association between GRIA4 polymorphisms and clinical improvement in patients with Major depressive disorder. PMID: 22057216
    6. SNPs within GRIA4 may not be associated with the development and treatment outcomes in BD PMID: 22122651
    7. No significant association GRIA4 polymorphisms was found with the diagnosis of schizophrenia. PMID: 22094384
    8. characterization of homomeric alpha-amino-3-hydroxy-5-methylisoxazolepropionate (AMPA)-selective GluR-D glutamate receptors carrying N-terminal deletions PMID: 12393905
    9. Results suggest that at least one susceptibility locus for schizophrenia is located within or very close to the GRIA4 region in Japanese. PMID: 12497607
    10. alternative splicing isoform of GluR4, human GluR4c has a 113-bp insert containing a stop codon, resulting in a short C terminus. PMID: 15306133
    11. The minimal kinetic mechanism for channel opening is consistent with binding of two glutamate molecules per receptor complex. PMID: 15823042
    12. GluR4 may regulate its synaptic targeting through phosphorylation-dependent interactions with alpha-Actinin-1 and IQGAP1 PMID: 16190873
    13. The present findings show that the interaction between PKCgamma and GluR4 is specifically required to assure PKC-driven phosphorylation and surface membrane expression of GluR4. PMID: 17233759

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendrite.
  • 蛋白家族：
    Glutamate-gated ion channel (TC 1.A.10.1) family, GRIA4 subfamily
  • 数据库链接：

    HGNC: 4574

    OMIM: 138246

    KEGG: hsa:2893

    STRING: 9606.ENSP00000282499

    UniGene: Hs.503743