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  4. Phospho-GRIN2B (Ser1303) Antibody

Phospho-GRIN2B (Ser1303) Antibody

  • 货号：
    CSB-PA071137
  • 规格：
    ￥2454
  • 图片：
    • Western blot analysis of extracts from Mouse brain cells using GRIN2B (Phospho-Ser1303) Antibody.The lane on the right is treated with the antigen-specific peptide.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) GRIN2B Polyclonal antibody
  • Uniprot No.：
    Q13224
  • 基因名：
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Peptide sequence around phosphorylation site of Serine 1303(Q-H-S(p)-Y-D) derived from Human GRIN2B.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death. Contributes to neural pattern formation in the developing brain. Plays a role in long-term depression (LTD) of hippocampus membrane currents and in synaptic plasticity.
  • 基因功能参考文献：
    1. This study demonstrated significant differences in the blood levels of GRIN2B between people with epilepsy and healthy subjects. PMID: 30140987
    2. There was no significant association between selected GRIN2B polymorphisms and personality traits. PMID: 29921740
    3. No association between GRIN2B rs1805502 polymorphism and OCD, symptom dimensions or treatment response in South Indian patients. PMID: 29321103
    4. Results showed that NRG1-ErbB4 signaling suppressed phosphorylation of GluN2B at position 1472 by Src kinase, and decreased levels of phosphorylation level of GluN2B and Src were detected in human symptomatic epilepsy tissues. PMID: 28273943
    5. Results suggest that alterations in the glutamate and dopamine system (GRIN2B and DRD4) in attention-deficit/hyperactivity disorder may contribute to abnormalities in local functional connectivity and its dynamic repertoire in the superior parietal area, and these abnormalities would be related to dysfunction in sustained and divided attention. PMID: 28258362
    6. GRIN2B SNP rs219927 is associated with brain volume in the left posterior cingulate cortex in adolescent alcohol dependence. PMID: 27498914
    7. The results suggest that the GRIN2B gene may modify the linguistic processes involved in the retrieval of information from the mental lexicon on the basis of semantic traits and, moreover, contribute to the variability of clinical symptoms of impairment of abstract thinking in patients with schizophrenia. PMID: 27240047
    8. It is this DAPK1-NR2B interaction that arbitrates the pathological processes like apoptosis, necrosis, and autophagy of neuronal cells observed in stroke injury, hence we aimed to inhibit this vital interaction to prevent neuronal damage. PMID: 28858643
    9. Five rare missense mutations in the GRIN2B gene are not associated with schizophrenia or autism spectrum disorder in a Japanese population. PMID: 27616045
    10. NR4A1 knockdown partly decreased surface NR2B by promoting NR2B internalization. PMID: 27876882
    11. This review showed that GRIN2B associate with Obsessive-compulsive disorder. PMID: 28608743
    12. GRIN2B polymorphism was associated with a twofold increase in odds of a Suicide Attempts in Alcohol-dependent individuals. PMID: 28558131
    13. GRIN2B encephalopathy is also frequently associated with movement disorder, cortical visual impairment and malformation of cortical development revealing novel phenotypic consequences of channelopathies. PMID: 28377535
    14. mutations of the human NMDAR were investigated and studied their consequences with kinetic modelling and electrophysiology. PMID: 29511171
    15. The polymorphisms in HTR2A and GRIN2B were significantly associated with increased risk of chronic obstructive pulmonary disease. PMID: 28900078
    16. In vitro DNA-binding and reporter gene assays of different allele combinations in transfected cells showed that the A allele was a gain-of-function variant associated with increasing GRIN2B mRNA levels PMID: 28439047
    17. Polymorphism C366G of gene GRIN2B and verbal episodic memory: No association with schizophrenia PMID: 29368832
    18. These preliminary results demonstrated that the GRIN2B gene may confer to some extent the susceptibility to OCD and its symptoms. PMID: 27394963
    19. Our finding confirms that early-onset EE may be caused not only by gain-of-function variants but also by splice site mutations-in particular those affecting the splice acceptor site of the 10th intron of the GRIN2B gene. PMID: 27605359
    20. Results indicate that the GRIN2B single nucleotide polymorphisms rs890 might be associated with schizophrenia in the Chinese Han population. PMID: 27453061
    21. These in vivo changes reflect changes in glutamate transporter protein in Huntington's disease (HD), mice and human HD post-mortem tissue. Furthermore, NAC was able to rescue changes in key glutamate receptor proteins related to excitotoxicity in HD, including NMDAR2B. PMID: 27179791
    22. Genetic association of CYP2B6*6 and GRIN2B (rs1019385 and rs1806191) single-nucleotide polymorphisms and ketamine-induced EP occurrence. PMID: 28252572
    23. In this review, mutations in GRIN2B were described as distributed throughout the entire gene in patients with neuropsychiatric and developmental disorders. PMID: 27818011
    24. Genetic variants were found in GluN2B from patients with neurological or psychiatric disorders resulting in reduced surface expression of GluN2B. PMID: 28283559
    25. SNP rs1806201 associated with earlier age at onset of withdrawal symptoms in Indian alcohol dependent subjects PMID: 26771436
    26. Multiple genetic variants in GRIN2B are jointly associated with gene expression, prefrontal function and behaviour during working memory (WM). These results support the role of GRIN2B genetic variants in WM prefrontal activity in human adults. PMID: 26690829
    27. Findings do not support a role for GRIN2B variants in altering response to clozapine in our sample of European patients with schizophrenia deemed resistant or intolerant to treatment PMID: 26876050
    28. both Arf6 activation through GluN2B-BRAG1 during early development and the transition from BRAG1- to BRAG2-dependent Arf6 signaling induced by the GluN2 subunit switch are critical for the development of mature glutamatergic synapses. PMID: 26884337
    29. GRIN2B (rs7301328) was significantly associated with disruptive behavior in adolescents. PMID: 26819771
    30. GRIN2B polymorphisms do not influence Parkinson disease age of onset in the US Caucasian population. PMID: 26627941
    31. GluN2B appears to exhibit allosteric regulation/inhibition by two distinct classes of antagonists; data from in silico docking suggest that GluN2B-selective antagonists broadly divide into two distinct classes according to binding pose. PMID: 26912815
    32. GRIN2B encodes the NR2 subunit of NMDA receptors, which are a class of ionotropic glutamate receptors involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission. PMID: 26321256
    33. ligand binding to cell surface GD2 induces rapid and transient activation of Src-family kinases, followed by Src-dependent phosphorylation of NMDA-receptor NR2B subunits selectively. PMID: 26252487
    34. Study provides evidence of an association between GRIN2B polymorphisms and Schizophrenia susceptibility and symptoms in the Han Chinese population. PMID: 26020650
    35. Polymorphisms in DRD1, DRD2 and GRIN2B confer increased risk of impulse control problems among PD patients. PMID: 25896831
    36. BDNF, APOE, and HSP70-1 genes, but not GRIN2B, might be associated with a risk of POAG occurrence in the Polish population PMID: 25893192
    37. This study provides further evidence in support of GRIN2B contributing toward Developmental Dyslexia and deficits in Developmental Dyslexia PMID: 25426763
    38. common variants and related haplotypes of GRIN2B are associated with autism risk. PMID: 25656819
    39. did not find significant pooled Odds Ratios for any of the six genes, under different models and stratifying for ethnicity. PMID: 25660313
    40. 421C/A polymorphism not associated with risk of occurrence of primary open-angle glaucoma PMID: 25693086
    41. The GluN2B-containing NMDA receptors (GluN2B/GluN1) were increased in schizophrenia in hippocampal CA3 tissue, but not in hippocampal CA1 tissue. PMID: 25585032
    42. The major depression subjects exhibited significantly higher expression levels of the NMDA receptor subunit genes GRIN2B. PMID: 24925192
    43. The results demonstrate the contribution of Grin2b via DISC1 on the risk of Schizophrenia PMID: 23855403
    44. first evidence of GluN2 protein abnormalities in the hippocampus in schizophrenia, highlighting the hippocampal lateralisation in this disorder. Only left hippocampus deficient in GluN2B. PMID: 25292222
    45. observations provide an initial delineation of the behavioral phenotype of GRIN2B mutation carriers. PMID: 23718928
    46. BDNF/TrkB signaling plays an important role in the NRG1-stimulated NR2B regulation. PMID: 25052836
    47. Association of GRIN2B gene polymorphisms with paranoid schizophrenia and response to common neuroleptics in Russians and Tatars from Bashkortostan Republic. PMID: 25486778
    48. Genetic polymorphisms and isogenic deletions of loop-bound sequences conferred liability for cognitive performance and decreased GRIN2B expression. PMID: 25467983
    49. Results advocate that genetic variability in GRIN2B gene, involved in synaptic functioning, might provide valuable insights into disease pathogenesis, continuing to attract significant attention in biomedical research on its genetic and functional role PMID: 24292895
    50. GRIN2B is likely to be related to neuro-developmental anomalies. PMID: 24503147

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  • 相关疾病：
    Mental retardation, autosomal dominant 6, with or without seizures (MRD6); Epileptic encephalopathy, early infantile, 27 (EIEE27)
  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Late endosome. Lysosome. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Glutamate-gated ion channel (TC 1.A.10.1) family, NR2B/GRIN2B subfamily
  • 组织特异性：
    Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia.
  • 数据库链接：

    HGNC: 4586

    OMIM: 138252

    KEGG: hsa:2904

    STRING: 9606.ENSP00000279593

    UniGene: Hs.504844