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Phospho-HIST1H1D (T146) Antibody

  • 货号:
    CSB-PA010379PA146phHU
  • 规格:
    ¥660
  • 促销:
    小规格抗体限时一口价
  • 图片:
    • Western Blot
      Positive WB detected in: PC-3 whole cell lysate
      All lanes: HIST1H1D antibody at 1µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 23 kDa
      Observed band size: 23 kDa
    • Immunofluorescence staining of Hela cells with CSB-PA010379PA146phHU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他:

产品详情

  • 产品名称:
    Rabbit anti-Homo sapiens (Human) HIST1H1D Polyclonal antibody
  • Uniprot No.:
    P16402
  • 基因名:
    HIST1H1D
  • 别名:
    H1 histone family member 3 antibody; H1.3 antibody; H13_HUMAN antibody; H1F3 antibody; HIST1 H1D antibody; HIST1H1D antibody; Histone 1 H1d antibody; Histone cluster 1 H1d antibody; Histone H1.3 antibody; Histone H1c antibody; MGC138176 antibody
  • 宿主:
    Rabbit
  • 反应种属:
    Human
  • 免疫原:
    Peptide sequence around site of Phospho-Thr (146) derived from Human Histone H1.3
  • 免疫原种属:
    Homo sapiens (Human)
  • 标记方式:
    Non-conjugated
  • 克隆类型:
    Polyclonal
  • 抗体亚型:
    IgG
  • 纯化方式:
    Antigen Affinity Purified
  • 浓度:
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式:
    Liquid
  • 应用范围:
    ELISA, WB, IF
  • 推荐稀释比:
    Application Recommended Dilution
    WB 1:200-1:2000
    IF 1:50-1:200
  • Protocols:
  • 储存条件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能:
    Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation.
  • 基因功能参考文献:
    1. Results show that histone H1.3, was identified only in non-neoplastic MCF-10A breast cells but not in metastatic MDA-MB-231 breast cancer cells . PMID: 26209608
    2. Histone H1 organizes and maintains an extensive protein-protein interaction network in the nucleolus required for nucleolar structure and integrity. PMID: 25584861
    3. overexpression of histone cluster 1 is associated with recurrence in meningiomas. PMID: 20685720
  • 亚细胞定位:
    Nucleus. Chromosome. Note=According to PubMed:15911621 more commonly found in euchromatin. According to PubMed:10997781 is associated with inactive chromatin.
  • 蛋白家族:
    Histone H1/H5 family
  • 数据库链接:

    HGNC: 4717

    OMIM: 142210

    KEGG: hsa:3007

    STRING: 9606.ENSP00000244534

    UniGene: Hs.136857