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  4. Phospho-NEK9 (T210) Antibody

Phospho-NEK9 (T210) Antibody

  • 货号：
    CSB-PA070248
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q8TD19
  • 基因名：
  • 别名：
    KIAA1995 antibody; APUG antibody; DKFZp434D0935 antibody; LCCS10 antibody; MGC138306 antibody; MGC16714 antibody; NC antibody; NEK 9 antibody; Nek8 antibody; nek9 antibody; NEK9_HUMAN antibody; Nercc 1 kinase antibody; NERCC antibody; NERCC1 antibody; Nercc1 kinase antibody; Never in mitosis A related kinase 9 antibody; Never in mitosis A-related kinase 9 antibody; NIMA (never in mitosis gene a) related kinase 9 antibody; NIMA related kinase 8 antibody; NIMA related kinase 9 antibody; NIMA related kinase Nek8 antibody; NimA related protein kinase 9 antibody; NIMA-related kinase 8 antibody; NimA-related protein kinase 9 antibody; Serine/threonine protein kinase Nek9 antibody; Serine/threonine-protein kinase Nek9 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from Human Nek9 around the phosphorylation site of T210.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively.
  • 基因功能参考文献：
    1. High expression level of NEK9 is associated with recurrence in glioblastoma. PMID: 26956052
    2. Signaling cascade of the NIMA-related kinases (Neks) Nek6, Nek7, and Nek9 is required for the localization and function of two kinesins essential for cytokinesis, Mklp2 and Kif14 to properly coordinate cytokinesis. PMID: 28630147
    3. Recessive NEK9 mutation is associated with lethal skeletal dysplasia. PMID: 26908619
    4. Somatic Mutations in NEK9 Cause Nevus Comedonicus. PMID: 27153399
    5. Overall, these results highlight the complexity of virus-host interactions and identify a new role for the cellular protein Nek9 during human adenovirus infection, suggesting a role for Nek9 in regulating p53 target gene expression. PMID: 26676776
    6. The C-terminal domain of Nek9 activates Nek7 through promoting back-to-back dimerization. PMID: 26522158
    7. The findings demonstrate that a novel NEK9 network regulates the growth of cancer cells lacking functional p53. PMID: 25131192
    8. NEK9 inhibition represents a novel anti-cancer strategy by induction of mitotic catastrophe via impairment of spindle dynamics, cytokinesis and mitotic checkpoint control. PMID: 23665325
    9. Structural analysis of LC8 with both Nek9 peptides, together with different biophysical experiments, explains the observed diminished binding affinity of Nek9 to LC8 upon phosphorylation on Ser(944) within the Nek9 sequence PMID: 23482567
    10. Nek9 phosphorylates NEDD1 on Ser377 driving its recruitment and thereby that of gamma-tubulin to the centrosome in mitotic cells. PMID: 22818914
    11. The interaction between the human NimA-like protein kinase Nek9 and the Helicobacter HcpC has been validated by ELISA and surface plasmon resonance. PMID: 21735226
    12. Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5. PMID: 21642957
    13. DYNLL/LC8 protein controls signal transduction through the Nek9/Nek6 signaling module by regulating Nek6 binding to Nek9. PMID: 21454704
    14. binds the Ran GTPase and regulates mitotic progression PMID: 12101123
    15. Activated in mitosis, and activates nek6 and nek7 kinase. PMID: 12840024
    16. mediates certain cellular processes, which are ultimately essential for interphase progression PMID: 14660563
    17. The disruption of a nuclear function of NEK9 by adenovirus E1A-associated cellular proteins is reported. PMID: 17443675
    18. The activity of Nek6 and Nek7, but not the tyrosine mutant, is increased by interaction with the Nek9 noncatalytic C-terminal domain, suggesting a mechanism in which the tyrosine is released from its autoinhibitory position. PMID: 19941817

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  • 相关疾病：
    Lethal congenital contracture syndrome 10 (LCCS10); Nevus comedonicus (NC); Arthrogryposis, Perthes disease, and upward gaze palsy (APUG)
  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Protein kinase superfamily, NEK Ser/Thr protein kinase family, NIMA subfamily
  • 组织特异性：
    Most abundant in heart, liver, kidney and testis. Also expressed in smooth muscle cells and fibroblasts.
  • 数据库链接：

    HGNC: 18591

    OMIM: 609798

    KEGG: hsa:91754

    STRING: 9606.ENSP00000238616

    UniGene: Hs.624721