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QTRT1 Antibody

  • 货号：
    CSB-PA887150LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: QTRT1 antibody at 6µg/ml
      Lane 1: MCF-7 whole cell lysate
      Lane 2: PC-3 whole cell lysate
      Lane 3: Jurkat whole cell lysate
      Lane 4: A431 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 45, 25 kDa
      Observed band size: 45 kDa
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA887150LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) QTRT1 Polyclonal antibody
  • Uniprot No.：
    Q9BXR0
  • 基因名：
    QTRT1
  • 别名：
    FP3235 antibody; Guanine insertion enzyme antibody; qtrt1 antibody; Queuine tRNA ribosyltransferase 1 antibody; Queuine tRNA ribosyltransferase antibody; Queuine tRNA-ribosyltransferase antibody; TGT antibody; TGT, 43 KD subunit antibody; TGT, catalytic subunit antibody; TGT_HUMAN antibody; TGUT antibody; tRNA guanine transglycosylase antibody; tRNA-guanine transglycosylase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Queuine tRNA-ribosyltransferase catalytic subunit 1 protein (211-403AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，QTRT1 Antibody (CSB-PA887150LA01HU)，的标记方式是Non-conjugated。对于QTRT1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA887150LB01HU QTRT1 Antibody, HRP conjugated ELISA
    FITC CSB-PA887150LC01HU QTRT1 Antibody, FITC conjugated
    Biotin CSB-PA887150LD01HU QTRT1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.
  • 基因功能参考文献：
    1. Homology models of C elegans Tgt and human Tgt suggest that the replacement of Cys158 and Val233 in bacterial Tgt (Zymomonas mobilis) by valine and accordingly glycine in eucaryotic Tgt largely accounts for the different substrate specificities. PMID: 23704982
    2. the inhibition of the human TGT by biopterin, consistent with earlier reports on other eukaryal TGTs, and supportive of the concept that pteridines may regulate eukaryal TGT activity in vivo. PMID: 21640076
    3. phylogenetic and kinetic analyses support the conclusion that all tRNA-guanine transglycosylases have divergently evolved to specifically recognize their cognate heterocyclic substrates. PMID: 21131277
  • 亚细胞定位：
    Cytoplasm. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族：
    Queuine tRNA-ribosyltransferase family
  • 数据库链接：

    HGNC: 23797

    OMIM: 609615

    KEGG: hsa:81890

    STRING: 9606.ENSP00000250237

    UniGene: Hs.631638