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RAB11FIP4 Antibody

  • 货号：
    CSB-PA003902
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HT29 cells using Rab11-FIP4 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q86YS3
  • 基因名：
  • 别名：
    RAB11FIP4 antibody; ARFO2 antibody; KIAA1821 antibody; Rab11 family-interacting protein 4 antibody; FIP4-Rab11 antibody; Rab11-FIP4 antibody; Arfophilin-2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Rab11-FIP4.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6.
  • 基因功能参考文献：
    1. Rab11-FIP4 expression promotes migration and invasion of colon cancer cells and correlates with poor prognosis. PMID: 29257314
    2. Our findings suggest that overexpression of Rab11-FIP4 predicts poor clinical outcomes for pancreatic cancer and contributes to pancreatic tumor progression. PMID: 28035375
    3. Results show the expression of Rab11-FIP4 upregulated in hepatocellular carcinoma (HCC) and correlated with poor prognosis. Rab11-FIP4 dramatically contributed to HCC metastasis via phosphorylation of PRAS40. PMID: 25745995
    4. Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells. PMID: 12470645
    5. FIP3 and FIP4 serve to couple Rab11-positive vesicle traffic from recycling endosomes to the cleavage furrow/midbody where they are tethered prior to fusion events via interactions with Arf6 and the Exocyst. PMID: 16148947

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  • 亚细胞定位：
    Endosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Recycling endosome membrane; Peripheral membrane protein. Cleavage furrow. Midbody. Cytoplasmic vesicle.
  • 组织特异性：
    Present at high level in testis (at protein level). Weakly expressed in other tissues.
  • 数据库链接：

    HGNC: 30267

    OMIM: 611999

    KEGG: hsa:84440

    STRING: 9606.ENSP00000312837

    UniGene: Hs.406788