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RAB11FIP5 Antibody

  • 货号：
    CSB-PA863141LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA863141LA01HU diluted at 1:400 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA863141LA01HU diluted at 1:400 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) RAB11FIP5 Polyclonal antibody
  • Uniprot No.：
    Q9BXF6
  • 基因名：
  • 别名：
    GAF 1 antibody; Gaf-1 antibody; GAF1 antibody; gamma SNAP associated factor 1 antibody; Gamma-SNAP-associated factor 1 antibody; KIAA0857 antibody; Phosphoprotein pp75 antibody; pp75 antibody; RAB11 family interacting protein 5 (class I) antibody; Rab11 family-interacting protein 5 antibody; Rab11 FIP5 antibody; Rab11 interacting protein antibody; Rab11 interacting protein Rip11 antibody; Rab11-FIP5 antibody; Rab11-interacting protein Rip11 antibody; Rab11fip5 antibody; RFIP5_HUMAN antibody; RIP11 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Rab11 family-interacting protein 5 protein (374-545AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，RAB11FIP5 Antibody (CSB-PA863141LA01HU)，的标记方式是Non-conjugated。对于RAB11FIP5 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA863141LB01HU RAB11FIP5 Antibody, HRP conjugated ELISA
    FITC CSB-PA863141LC01HU RAB11FIP5 Antibody, FITC conjugated
    Biotin CSB-PA863141LD01HU RAB11FIP5 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis.
  • 基因功能参考文献：
    1. FIP5-T276 phosphorylation occurs specifically during metaphase and anaphase. PMID: 24591568
    2. FIP5-SNX18 complex plays a pivotal role in the polarized transport of apical proteins during apical lumen initiation in epithelial cells. PMID: 21969467
    3. These data introduce Rab11b as a crucial regulator and Rip11 as mediator of acidosis-induced V-ATPase traffic in duct cells of submandibular gland. PMID: 20717956
    4. analysis of the rearrangement breakpoints suggests that the reciprocal translocation may have formed secondary to incorrect repair of double strand breaks (DSBs) by nonhomologous end-joining (NHEJ). PMID: 18384058
  • 亚细胞定位：
    Cytoplasm. Recycling endosome membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Mitochondrion membrane; Peripheral membrane protein.
  • 组织特异性：
    Detected at low levels in heart, brain, placenta, lung, liver, adipocytes, kidney, spleen, skeletal muscle and pancreas.
  • 数据库链接：

    HGNC: 24845

    OMIM: 605536

    KEGG: hsa:26056

    STRING: 9606.ENSP00000258098

    UniGene: Hs.24557