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RAB3D Antibody

  • 货号：
    CSB-PA955238
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA955238(Rab3D Antibody) at dilution 1/27, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA955238(Rab3D Antibody) at dilution 1/27, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    O95716
  • 基因名：
  • 别名：
    D2-2 antibody; Glioblastoma overexpressed antibody; GOV antibody; RAB 16 antibody; RAB16 antibody; Rab3d antibody; Rab3D upregulated with myeloid differentiation antibody; RAB3D; member RAS oncogene family antibody; RAB3D_HUMAN antibody; RAD3D antibody; Ras-related protein Rab-3D antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human Rab3D
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:10000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Protein transport. Probably involved in regulated exocytosis.
  • 基因功能参考文献：
    1. targeting the Rab3D may be a potential therapeutic target for treatment of esophageal squamous cell carcinoma. PMID: 28472755
    2. increased Rab3D expression is associated with invasiveness of CRC cells PMID: 27046094
    3. High expression of small GTPase Rab3D promotes cancer progression and metastasis. PMID: 25823663
    4. The presence of Rab3D(N135I) decreases the restriction of maturing secretory granules (SGs) to the F-actin-rich cell cortex, blocks the removal of the endoprotease furin from SGs and impedes the processing of the luminal SG protein secretogranin II. PMID: 23526941
    5. Our findings indicate that Rab3D regulates the exocytosis of many components critical for the maintenance of oral physiology. PMID: 21702009
    6. MIST1 binds to highly conserved CATATG E-boxes to directly activate transcription of 6 genes, including those encoding the small GTPases RAB26 and RAB3D. PMID: 20038531
    7. mutant Rab3D proteins interfere with the formation of bona fide Weibel-Palade bodies and consequently the acute, histamine-induced release of von-Willebrand factor PMID: 15257287

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor; Cytoplasmic side.
  • 蛋白家族：
    Small GTPase superfamily, Rab family
  • 组织特异性：
    Highly expressed in granulocytes of peripheral blood. Constitutively expressed at low levels in all hematopoietic cell lines investigated.
  • 数据库链接：

    HGNC: 9779

    OMIM: 604350

    KEGG: hsa:9545

    STRING: 9606.ENSP00000222120

    UniGene: Hs.744916