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RANBP10 Antibody

  • 货号：
    CSB-PA764955LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: SH-SY5Y whole cell lysate, Hela whole cell lysate, MCF-7 whole cell lysate
      All lanes: RANBP10 antibody at 2.1μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 68, 59, 65 kDa
      Observed band size: 68 kDa
    • IHC image of CSB-PA764955LA01HU diluted at 1:200 and staining in paraffin-embedded human skeletal muscle tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunoprecipitating RANBP10 in Rat brain tissue
      Lane 1: Rabbit control IgG instead of CSB-PA764955LA01HU in Rat brain tissue. For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
      Lane 2: CSB-PA764955LA01HU (6µg) + Rat brain tissue (1mg)
      Lane 3: Rat brain tissue (20µg)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) RANBP10 Polyclonal antibody
  • Uniprot No.：
    Q6VN20
  • 基因名：
    RANBP10
  • 别名：
    FLJ31165 antibody; KIAA1464 antibody; RAN binding protein 10 antibody; Ran-binding protein 10 antibody; RanBP10 antibody; RBP10_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Rat
  • 免疫原：
    Recombinant Human Ran-binding protein 10 protein (3-165AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，RANBP10 Antibody (CSB-PA764955LA01HU)，的标记方式是Non-conjugated。对于RANBP10 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA764955LB01HU RANBP10 Antibody, HRP conjugated ELISA
    FITC CSB-PA764955LC01HU RANBP10 Antibody, FITC conjugated
    Biotin CSB-PA764955LD01HU RANBP10 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IP
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:200-1:500
    IP 1:200-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase. May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function.
  • 基因功能参考文献：
    1. s provide evidence that enhancement of neuronal morphology through RANBP10 is one of the neuroprotective mechanisms for miR-196a. PMID: 28744327
    2. The results showed that ICP0 interacted with cell protein RanBP10, a known transcriptional coactivator, in human herpesvirus 1-infected cells. PMID: 26739050
    3. data support the idea that RanBP9 and RanBP10 may function as signaling integrators and dictate the efficient regulation of D(1) receptor signaling by PKCdelta and PKCgamma PMID: 20395553
    4. RanBP10 might serve as a molecular link between Ran and noncentrosomal microtubules PMID: 18347012
  • 亚细胞定位：
    Cytoplasm, cytosol. Nucleus. Note=Predominantly cytoplasmic.
  • 蛋白家族：
    RANBP9/10 family
  • 组织特异性：
    Broadly expressed, with highest levels in skeletal muscle.
  • 数据库链接：

    HGNC: 29285

    OMIM: 614031

    KEGG: hsa:57610

    STRING: 9606.ENSP00000316589

    UniGene: Hs.368569