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RAP2B Antibody

  • 货号：
    CSB-PA019327ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA019327ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA019327ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) RAP2B Polyclonal antibody
  • Uniprot No.：
    P61225
  • 基因名：
    RAP2B
  • 别名：
    MGC20484 antibody; RAP 2B antibody; RAP2A antibody; Rap2b antibody; RAP2B member of RAS oncogene family antibody; RAP2B_HUMAN antibody; Ras family small GTP binding protein RAP2B antibody; Ras related protein RAP 2B antibody; Ras related protein RAP2B antibody; Ras-related protein Rap-2b antibody; Small GTP binding protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Ras-related protein Rap-2b protein (1-183AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells.
  • 基因功能参考文献：
    1. Rap2B was overexpressed in cervical cancer tissues and cell lines and knockdown of Rap2B inhibited cervical cancer cell proliferation, migration, and invasion in vitro and suppressed cervical cancer cell growth and metastasis in vivo PMID: 28390112
    2. these results revealed that Rap2B promotes renal cell carcinoma angiogenesis via phosphoinositide 3-kinase/AKT/vascular endothelial growth factor signaling pathway, which suggests that Rap2B is a novel therapeutic target for renal cell carcinoma anti-angiogenesis therapy. PMID: 28691643
    3. our results suggested that Rap2b may be a potential therapeutic target for lung cancer. PMID: 26671640
    4. knockdown of Rap2B inhibits the proliferation and invasion in HCC cells. These findings reveal that Rap2B plays an important role in the regulation of HCC progression. PMID: 28081729
    5. miR-194 is inversely correlated with RAP2B. PMID: 27133066
    6. Western blot analysis uncovered that elevated Rap2B leads to increased phosphorylation levels of FAK, suggesting that FAK-dependent pathway might be responsible for the effect of Rap2B on PCa cells migration and invasion. PMID: 27154636
    7. Expression and DNA methylation status of the Rap2B gene in human bronchial epithelial cells treated by cigarette smoke condensate PMID: 26308105
    8. Our collective findings provide preliminary evidence that miR-342-3p acts as a tumor suppressor in small cell lung cancer through repression of RAP2B. PMID: 25663460
    9. Rap2B itself is not necessary for p53-dependent cell cycle arrest. PMID: 25762091
    10. Data indicate that rap GTP-binding protein Rap2B expression is significantly increased in suprarenal epithelioma and Rap2B can promote the cell migration and invasion abilities, suggesting a target for the treatment of suprarenal epithelioma. PMID: 24951956
    11. Rap2b is a conserved p53-activated gene that counters p53-mediated apoptosis after DNA damage. PMID: 23535297
    12. Rap2b mediates the pro-survival function of p53 upon DNA damage. PMID: 23535297
    13. Stimulation of phospholipase C-epsilon by the M3 muscarinic acetylcholine receptor mediated by cyclic AMP and the GTPase Rap2B PMID: 11877431
    14. the small GTPase Rap2B is involved in platelet activation PMID: 15613030
    15. A cDNA library consisting of 220 upregulated genes in tumour tissue was established and named as LSCC. Differential expression was confirmed in five of these genes, including IGFBP5, SQLE, RAP2B, CLDN1, and TBL1XR1. PMID: 17316888

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  • 亚细胞定位：
    Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Note=Associated with red blood cells-released vesicles.
  • 蛋白家族：
    Small GTPase superfamily, Ras family
  • 组织特异性：
    Expressed in red blood cells (at protein level).
  • 数据库链接：

    HGNC: 9862

    OMIM: 179541

    KEGG: hsa:5912

    STRING: 9606.ENSP00000319096

    UniGene: Hs.700713