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RASAL2 Antibody

  • 货号：
    CSB-PA890908LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA890908LA01HU diluted at 1:200 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of Hela cells with CSB-PA890908LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) RASAL2 Polyclonal antibody
  • Uniprot No.：
    Q9UJF2
  • 基因名：
  • 别名：
    nGAP antibody; NGAP_HUMAN antibody; Ras GTPase-activating protein nGAP antibody; Ras protein activator like 1 antibody; RAS protein activator-like 2 antibody; RASAL2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Ras GTPase-activating protein nGAP protein (749-835AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，RASAL2 Antibody (CSB-PA890908LA01HU)，的标记方式是Non-conjugated。对于RASAL2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA890908LB01HU RASAL2 Antibody, HRP conjugated ELISA
    FITC CSB-PA890908LC01HU RASAL2 Antibody, FITC conjugated
    Biotin CSB-PA890908LD01HU RASAL2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Inhibitory regulator of the Ras-cyclic AMP pathway.
  • 基因功能参考文献：
    1. Furthermore, overexpression of miR-203 exhibited a similar effect to RASAL2 knockdown in hepatocellular carcinoma (HCC) cells. These results indicated that RASAL2 serves a tumor oncogenic role in HCC and may be considered a potential target in HCC. PMID: 28447723
    2. Study shows that up to 62% of luminal B cancers have lost expression of at least one of the DAB2IP and RASAL2 genes. However, the tumors that have lost both genes frequently present as advanced disease and are more likely to recur. Importantly, the report provide evidence that DAB2IP and RASAL2 can individually function as tumor suppressors in breast cancer. PMID: 27974415
    3. RASAL2 could inhibit BCa tumorigenesis. PMID: 28182001
    4. these results demonstrated that miRNA-136 was a key anti-invasive miRNA and further confirmed the oncogenic role of RASAL2 in triple-negative breast cancer. PMID: 27108696
    5. High RASAL2 expression is associated with liver cancer. PMID: 24763612
    6. these results indicate that activation of a RASAL2/ARHGAP24/RAC1 module contributes to TNBC tumorigenesis and identify a context-dependent role of RASAL2 in breast cancer. PMID: 25384218
    7. Results implicate RASAL2 as an EMT regulator and tumor suppressor in ovarian cancer, and down-regulation of RASAL2 promotes ovarian cancer progression. PMID: 25216515
    8. the down-regulation of RASAL2 promotes metastatic progression of lung adenocarcinoma PMID: 25446096
    9. The RasGAP gene, RASAL2, is a tumor and metastasis suppressor. PMID: 24029233
    10. RASAL2 was identified as an ECT2-interacting protein that regulates RHO activity in astrocytoma cells. PMID: 22683310

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  • 数据库链接：

    HGNC: 9874

    OMIM: 606136

    KEGG: hsa:9462

    STRING: 9606.ENSP00000356621

    UniGene: Hs.496139