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RASSF4 Antibody

  • 货号：
    CSB-PA003944
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HuvEc cells using RASSF4 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9H2L5
  • 基因名：
    RASSF4
  • 别名：
    3830411C14Rik antibody; AD037 antibody; AI586137 antibody; MGC105606 antibody; MGC44914 antibody; OTTHUMP00000019493 antibody; Ras association (RalGDS/AF 6) domain family 4 antibody; Ras association (RalGDS/AF 6) domain family member 4 antibody; Ras association domain containing protein 4 antibody; Ras association domain family 4 antibody; Ras association domain-containing protein 4 antibody; RASF4_HUMAN antibody; RASSF 4 antibody; Rassf4 antibody; RP11-285G1.4 antibody; Tumor suppressor RASSF4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human RASSF4.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest.
  • 基因功能参考文献：
    1. RASSF4 controls store operated calcium entry and endoplasmic reticulum-plasma membrane junctions through ARF6-dependent regulation of PM PI(4,5)P2 levels, pivotal for a variety of physiological processes. PMID: 28600435
    2. RASSF4 overexpression inhibits proliferation, invasion, EMT, and Wnt signaling pathway in osteosarcoma cells. PMID: 28081736
    3. the present study suggested that RASSF4 serves as an important tumor suppressor in human nonsmall cell lung cancer . PMID: 26526576
    4. RASSF4 promotes EV71 replication and the production of viral progeny to accelerate the inhibition of the phosphorylation of AKT. PMID: 25701784
    5. expression of SPRR1B is upregulated in oral CSCs/CICs and SPRR1B has a role in cell growth by suppression of RASSF4 PMID: 23954638
    6. Single nucleotide polymorphism in RASSF4 gene is associated with acute lymphoblastic leukemia. PMID: 19066393

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  • 组织特异性：
    Widely expressed. Frequently down-regulated in tumor cell lines.
  • 数据库链接：

    HGNC: 20793

    OMIM: 610559

    KEGG: hsa:83937

    STRING: 9606.ENSP00000339692

    UniGene: Hs.522895