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RASSF7 Antibody

  • 货号：
    CSB-PA060185
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q02833
  • 基因名：
    RASSF7
  • 别名：
    C11orf13 antibody; Chromosome 11 open reading frame 13 antibody; HRAS1 antibody; HRAS1 related cluster 1 antibody; HRAS1 related cluster protein 1 antibody; HRAS1-related cluster protein 1 antibody; HRC1 antibody; MGC126069 antibody; MGC126070 antibody; Ras association (RalGDS/AF 6) domain family (N terminal) member 7 antibody; Ras association (RalGDS/AF 6) domain family 7 antibody; Ras association domain containing protein 7 antibody; Ras association domain-containing protein 7 antibody; RASF7_HUMAN antibody; RASSF 7 antibody; RASSF7 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human RASSF7.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti-apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization.
  • 基因功能参考文献：
    1. RASSF7 promotes cell proliferation through activating MEK1/MEK2-ERK1/ERK2 signaling pathway in hepatocellular carcinoma. PMID: 29729697
    2. Suggest that loss of RASSF7 expression results in apoptosis in nucleus pulposus cells in human intervertebral disc degeneration. PMID: 26884887
    3. truncated RASSF7 could act as an oncogene in a small subset of tumours where it is mutated in this way. PMID: 26569555
    4. The RASSF gene family members RASSF5, RASSF6 and RASSF7 show frequent DNA methylation in neuroblastoma. PMID: 22695170
    5. RASSF7 acts in concert with N-Ras to constitute a stress-sensitive temporary mechanism of apoptotic regulation. PMID: 21278800
    6. RASSF7 regulates the microtubule cytoskeleton and is required for spindle formation, Aurora B activation and chromosomal congression during mitosis. PMID: 20629633
    7. rare alleles of HRas1 minisatellite are associated with increased risk of papillary thyroid cancer formation in children and adolescents after Chernobyl accident PMID: 15098441

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with gamma-tubulin.
  • 数据库链接：

    HGNC: 1166

    OMIM: 143023

    KEGG: hsa:8045

    STRING: 9606.ENSP00000344226

    UniGene: Hs.72925