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  4. RBBP6 Antibody

RBBP6 Antibody

  • 货号：
    CSB-PA019391GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q7Z6E9
  • 基因名：
    RBBP6
  • 别名：
    DKFZp686P0638 antibody; DKFZp761B2423 antibody; E3 ubiquitin-protein ligase RBBP6 antibody; MY038 antibody; P2P R antibody; P2PR antibody; p53 associated cellular protein of testis antibody; p53-associated cellular protein of testis antibody; p53-associated cellular protein, testis-derived antibody; PACT antibody; Proliferation potential related protein antibody; Proliferation potential-related protein antibody; Protein P2P R antibody; Protein P2P-R antibody; Protein P2PR antibody; Protein RBQ 1 antibody; Protein RBQ1 antibody; RB binding protein 6, ubiquitin ligase antibody; RB binding Q protein 1 antibody; RBBP 6 antibody; Rbbp6 antibody; RBBP6_HUMAN antibody; RBQ 1 antibody; RBQ-1 antibody; RBQ1 antibody; Retinoblastoma binding protein 6 isoform 3 antibody; Retinoblastoma binding Q protein 1 antibody; Retinoblastoma-binding protein 6 antibody; Retinoblastoma-binding Q protein 1 antibody; SNAMA antibody; SNAMA, Drosophila, homolog of antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Human RBBP6
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

问答及客户评论

■ 常见问题解答
Q:

我已经订购了抗体CSB-PA019391GA01HU。它检测到的size是多少？

A:
抗体CSB-PA019391GA01HU检测到201 kDa左右的靶蛋白。对HEK-293细胞进行SDS-PAGE，然后用CSB-PA019391GA01HU进行western blot，稀释比例为1:400，室温孵育1.5小时。

靶点详情

  • 功能：
    E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth. Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication.; (Microbial infection) restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription.
  • 基因功能参考文献：
    1. RBBP6 might potentiate cervical carcinoma cell viability. PMID: 29501043
    2. Results from a study on gene expression variability markers in early-stage human embryos shows that RBBP6 is a putative expression variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
    3. RBBP6 overexpression could resist colorectal cancer cells against radiation. PMID: 29369481
    4. These results suggest that the RBBP6-3 isoform may be involved in promoting apoptosis in cancerous cells. PMID: 26905308
    5. RBBP6 is a candidate gene for myeloproliferative neoplasms (MPNs) susceptibility in a subset of pedigrees with familial MPN. PMID: 26574608
    6. High expression levels of RBBP6 and high apoptosis levels were found in HIV-associated nephropathy (HIVAN) cases. This direct association between RBBP6 expression and apoptosis levels suggests that RBBP6 play a role in HIVAN pathogenesis. PMID: 25910411
    7. gene silencing sensitises breast cancer cells to staurosporine and camptothecin-induced cell death PMID: 24703106
    8. RBBP6 prevents DNA damage by destabilizing the transcriptional repressor ZBTB38. PMID: 24726359
    9. RBBP6 gene variants are associated with glioma and contribute to glioma susceptibility PMID: 25127414
    10. implicate RBBP6 and iso3 as novel regulators of 3' processing, especially of RNAs with AU-rich 3' UTRs. PMID: 25319826
    11. these findings suggest that RBBP6 isoform 3 is a cell cycle regulator and may be deregulated in carcinogenesis PMID: 22139301
    12. AGO2, PACT and TRBP are required for the efficient functioning of Dicer in cells PMID: 22163034
    13. Taken together with the structural similarities to U-box-containing proteins, our data suggest that RBBP6 plays a role in chaperone-mediated ubiquitination and possibly in protein quality control. PMID: 22130672
    14. RBBP6 may be involved in the degradation of p53, thereby enhancing cell proliferation and inhibiting apoptosis in lung cancer. PMID: 21676486
    15. P2P-R expression may be translationally regulated by PUM2 and that P2P-R may modulate translation by influencing ribosomal protein gene expression PMID: 15617101
    16. RBBP6 has a role in mRNA processing and ubiquitin-like pathways PMID: 16396680
    17. The s showed that RBBP6 and its isolated RING finger domain were able to ubiquitinate YB-1, resulting in its degradation in the proteosome. As a result, RBBP6 was able to suppress the levels of YB-1 in vivo and reduce its transactivational ability. PMID: 18851979

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  • 亚细胞定位：
    Nucleus, nucleolus. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with mitotic chromosomes. Colocalizes with NEK6 in the centrosome.
  • 组织特异性：
    Highly expressed in the placenta and testis. Expressed at lower levels in the brain, heart, kidney, liver and lung. Overexpressed in esophageal cancer.
  • 数据库链接：

    HGNC: 9889

    OMIM: 600938

    KEGG: hsa:5930

    STRING: 9606.ENSP00000317872

    UniGene: Hs.188553