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RBM10 Antibody

  • 货号：
    CSB-PA019400GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P98175
  • 基因名：
  • 别名：
    DXS8237E antibody; G patch domain containing protein 9 antibody; G patch domain-containing protein 9 antibody; GPATC9 antibody; GPATCH9 antibody; HGNC9896 antibody; KIAA0122 antibody; MGC1132 antibody; MGC997 antibody; Rbm10 antibody; RBM10_HUMAN antibody; RNA binding motif protein 10 antibody; RNA binding protein 10 antibody; RNA binding protein S1-1 antibody; RNA-binding motif protein 10 antibody; RNA-binding protein 10 antibody; RNA-binding protein S1-1 antibody; S1-1 antibody; TARPS antibody; ZRANB5 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human RBM10
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May be involved in post-transcriptional processing, most probably in mRNA splicing. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A). May bind to specific miRNA hairpins.
  • 基因功能参考文献：
    1. RBM10: Harmful or helpful-many factors to consider. PMID: 29274279
    2. RBM10 mutations contribute to lung adenocarcinoma pathogenesis. PMID: 28091594
    3. The high rate of TERT promoter mutations, MED12 mutations, RBM10 mutations, and chromosome 1q gain highlight their likely association with tumor virulence PMID: 28634282
    4. The well-known high-fidelity RNA splice site recognition by RBM10, and probably by RBM5 and RBM6, can thus be largely rationalized by a cooperative binding action of RRM and ZnF domains PMID: 29450990
    5. Our work has not only expanded the number of pre-mRNA targets for RBM10, but identified RBM10 as a novel regulator of SMN2 alternative inclusion. PMID: 28728573
    6. RBM10 functions as a splicing regulator using two RNA-binding units with different specificities to promote exon skipping. PMID: 28379442
    7. RNA binding motif protein 10 (RBM10) negatively regulates its own mRNA and protein expression and that of RNA binding motif protein 5 (RBM5) by promoting alternative splicing-coupled nonsense-mediated mRNA decay (AS-NMD). PMID: 28586478
    8. results provide evidence that RBM10 expression, in RBM5-null tumors, may contribute to tumor growth and metastasis. Measurement of both RBM10 and RBM5 expression in clinical samples may therefore hold prognostic and/or potentially predictive value PMID: 28662214
    9. RBM10-TFE3 is a recurrent gene fusion in Xp11 translocation renal cell carcinoma. PMID: 28296677
    10. Xp11 translocation renal cell carcinomas with RBM10-TFE3 gene fusion demonstrating melanotic features and overlapping morphology with t(6;11) RCC. PMID: 28288037
    11. RNA-binding motif 10 messenger RNA and protein were reduced in lung adenocarcinoma tissues, and RNA-binding motif 10 overexpression inhibited lung adenocarcinoma cancer cell malignant behavior in vitro. Molecularly, RNA-binding motif 10 regulates many gene pathways involving in the tumor development or progression. PMID: 28347232
    12. RBM10-TFE3 fusion variant (from chromosome X paracentric inversion), therefore, appears to be a recurrent molecular event in Xp11.2 RCCs. RBM10-TFE3 fusion should be added in the list of screened fusion transcripts in targeted molecular diagnostic multiplex RT-PCR PMID: 26998913
    13. RBM10 is a tumor suppressor that represses Notch signaling and cell proliferation through the regulation of NUMB alternative splicing PMID: 26853560
    14. Src family tyrosine kinase signaling may regulate FilGAP through association with RBM10 PMID: 26751795
    15. The ability of RBM10v1 to regulate alternative splicing depends, at least in part, on a structural alteration within the second RNA recognition motif domain, and correlates with preferential expression of the NUMB exon 11 inclusion variant. PMID: 25889998
    16. RBM10 regulates alternative splicing of Fas and Bcl-x genes. PMID: 24530524
    17. Antagonizes the effects of RBM5, RBM6, and RBM10 in cell colony formation. PMID: 24332178
    18. This study established RBM10 as an important regulator of alternative splicing, presented a mechanistic model for RBM10-mediated splicing regulation and provided a molecular link to understanding a human congenital disorder. PMID: 24000153
    19. S1-1 contains multiple nuclear localisation sequence that act cooperatively. PMID: 23294349
    20. Massively parallel sequencing of exons on the X chromosome identifies RBM10 as the gene that causes a syndromic form of cleft palate. PMID: 20451169
    21. From these results, it seems that the X-chromosome, through its RBM genes, plays a formerly unknown role in the regulation of programmed cell death (apoptosis) in breast cancer. PMID: 16552754
    22. S1-1 constitutes hundreds of nuclear domains, which dynamically change their structures in a reversible manner; upon globally reducing RNA polymerase II transcription, S1-1 nuclear bodies enlarge and decrease in number. PMID: 18315527
    23. results indicate that very few genes are involved in the last steps of the apoptotic cascade in breast cancer, among them one of the X-chromosome RBM family PMID: 18820371

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  • 相关疾病：
    TARP syndrome (TARPS)
  • 亚细胞定位：
    Nucleus. Note=In the extranucleolar nucleoplasm constitutes hundreds of nuclear domains, which dynamically change their structures in a reversible manner. Upon globally reducing RNA polymerase II transcription, the nuclear bodies enlarge and decrease in number. They occur closely adjacent to nuclear speckles or IGCs (interchromatin granule clusters) but coincide with TIDRs (transcription-inactivation-dependent RNA domains).
  • 数据库链接：

    HGNC: 9896

    OMIM: 300080

    KEGG: hsa:8241

    STRING: 9606.ENSP00000366829

    UniGene: Hs.401509