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RBM17 Antibody

  • 货号：
    CSB-PA019408GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q96I25
  • 基因名：
    RBM17
  • 别名：
    45 kDa-splicing factor antibody; RBM 17 antibody; Rbm17 antibody; RNA binding motif protein 17 antibody; RNA-binding motif protein 17 antibody; SPF 45 antibody; SPF45 antibody; SPF45_HUMAN antibody; Splicing factor (45 kD) antibody; Splicing factor (45kD) antibody; Splicing factor 45 antibody; Splicing factor 45 kDa antibody; Splicing factor 45kDa antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human RBM17
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia.
  • 基因功能参考文献：
    1. this work provides the structural and molecular basis of the interaction between RBM17 and the phosphorylated form of ATXN1. PMID: 24858692
    2. identify SPF45 as the first splicing factor regulated by multiple MAP kinase pathways and show effects of both SPF45 overexpression and phosphorylation PMID: 22615491
    3. dephosphorylation of pS776-ATXN1 by PP2A regulates the interaction of ATXN1 with the splicing factors RBM17 and U2AF65 PMID: 21835928
    4. overexpression of SPF45 in HeLa, a cervical carcinoma cell line, resulted in drug resistance to doxorubicin and vincristine PMID: 14578179
    5. The SPF45 regulates alternative splicing of the apoptosis regulatory gene CD95; 2.1-A crystal structure of SPF45-UHM in complex with a ULM peptide from SF3b155 is reported. PMID: 17589525
    6. Resistance to various chemotherapeutics resulting from stable transfection of RBM17 (SPF45) in A2780 ovarian carcinoma cells may be due to effects of SPF45 on transcription and splicing of ERbeta-regulated genes. PMID: 16061639

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 16944

    OMIM: 606935

    KEGG: hsa:84991

    STRING: 9606.ENSP00000369218

    UniGene: Hs.498548