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  4. RBM39 Antibody

RBM39 Antibody

  • 货号：
    CSB-PA019424GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q14498
  • 基因名：
    RBM39
  • 别名：
    CAPER alpha antibody; CAPER antibody; CAPERalpha antibody; CC1.3 antibody; Coactivator of activating protein 1 and estrogen receptors antibody; Coactivator of AP1 and ERs antibody; DKFZp781C0423 antibody; FLJ44170 antibody; HCC 1 antibody; Hepatocellular carcinoma protein 1 antibody; RBM 39 antibody; RBM39 antibody; RBM39_HUMAN antibody; RNA binding motif protein 39 antibody; RNA binding region (RNP1 RRM) containing 2 antibody; RNA binding region containing 2 antibody; RNA binding region containing protein 2 antibody; RNA-binding motif protein 39 antibody; RNA-binding protein 39 antibody; RNA-binding region-containing protein 2 antibody; RNPC 2 antibody; RNPC2 antibody; Splicing factor CC1.3 antibody; Splicing factor CC1.4 antibody; Splicing factor HCC 1 antibody; Splicing factor HCC1 antibody; Transcription coactivator CAPER antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human RBM39
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    RNA-binding protein that acts as a pre-mRNA splicing factor. Acts by promoting exon inclusion via regulation of exon cassette splicing. Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1, independently of the pre-mRNA splicing factor activity.
  • 基因功能参考文献：
    1. Decreased expression of CAPERalpha appears to be correlated with appearance of microvessels in hepatocellular carcinoma PMID: 26934653
    2. RBM39 is extensively involved in alternative splicing of RNA and helps regulate transcript levels. RBM39 may modulate alternative splicing similarly to U2AF65 by either directly binding to RNA or recruiting other splicing factors, such as U2AF65. PMID: 27354116
    3. The results provide a mechanism for exon 16 3' splice site activation in which a coordinated effort among TIA1, Pcbp1, and RBM39 stabilizes or increases U2 snRNP recruitment, enhances spliceosome A complex formation, and facilitates exon definition through RBM39-mediated splicing regulation. PMID: 28193846
    4. This study therefore establishes a structural basis for specific UHM-ULM interactions by splicing factors such as U2AF35, U2AF65, RBM39 and SF3b155, and a platform for continued studies of intermolecular interactions governing disease-related alternative splicing in eukaryotic cells. PMID: 27050129
    5. mammalian c-Abl plays an important role in steroid hormone receptor-mediated transcription by regulating RBM39 PMID: 27018250
    6. Knockdown of CAPER expression markedly reduced human breast cancer cell proliferation in both in vitro and in vivo settings. Mechanistically, knockdown of CAPER abrogated the activity of proliferative and protein synthesis pathways. PMID: 24621503
    7. Our data suggest that overexpression of HCC1/CAPERalpha may increase the proliferation and migration of NSCLC cells, and HCC1/CAPERalpha could be a promising biomarker for lung cancer PMID: 24643682
    8. identify SF3b155 as the relevant ULM-containing partner of full-length CAPERalpha in human cell extracts. PMID: 24795046
    9. Data show that CSE1L, DIDO1 and RBM39 mRNA expression levels correlated with chromosome 20q DNA copy number status. PMID: 22711543
    10. Increased VEGF(165) expression is secondary to the down-regulation of CAPER-alpha by EWS/FLI-1. CAPER-alpha mediates alternative splicing and controls the shift from VEGF(189) to VEGF(165) . PMID: 22009261
    11. 10 genes were down-regulated following treatment of the T-ALL cells with 0.15 and 1.5 microg/mL of metal ores at 72 h PMID: 15747776
    12. this study identifies CAPERalpha (RNA binding motif protein 39) as a new transcriptional coregulator for v-Rel and reveals an important role in modulating Rel's oncogenic activity. PMID: 18753212
    13. Analysis of human breast cancer samples revealed that CAPER is overexpressed and undergoes a cytoplasmic-to-nuclear shift during the transition from pre-malignancy to ductal carcinoma in situ PMID: 19342371
    14. This paper describes the mouse gene. PMID: 11704680

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  • 亚细胞定位：
    Nucleus speckle.
  • 蛋白家族：
    Splicing factor SR family
  • 组织特异性：
    Widely expressed. Highly expressed in pancreas, skeletal muscle, lung and brain. Expressed at intermediate level in kidney, liver and heart.
  • 数据库链接：

    HGNC: 15923

    OMIM: 604739

    KEGG: hsa:9584

    STRING: 9606.ENSP00000253363

    UniGene: Hs.282901