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RBP2 Antibody

  • 货号：
    CSB-PA005623
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of K562 cells using CRBP II Polyclonal Antibody.
  • 其他：

产品详情

  • Uniprot No.：
    P50120
  • 基因名：
    RBP2
  • 别名：
    Cellular retinol binding protein II antibody; Cellular retinol-binding protein II antibody; CRABP II antibody; Crbp 2 antibody; CRBP II antibody; CRBP-II antibody; CRBP2 antibody; CrbpII antibody; MGC159254 antibody; MGC159256 antibody; Rbp 2 antibody; Rbp2 antibody; RBPC2 antibody; RET2_HUMAN antibody; Retinol binding protein 2 antibody; Retinol binding protein 2 cellular antibody; Retinol-binding protein 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human CRBP II.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Intracellular transport of retinol.
  • 基因功能参考文献：
    1. study demonstrates that Piasy may prevent exaggerated transcription of IFNI by Rbp2-mediated demethylation of H3K4me3 of IFNI, avoiding excessive immune responses PMID: 28970247
    2. Domain-swapped dimers of RBP2 provides evidence for ordered folding intermediates. PMID: 27524203
    3. The structure of retinal-bound human CRBPII and the structure of retinol-bound CRBPII with retinol fully occupying the binding pocket are reported. PMID: 25478840
    4. With only nine point mutations, the hCRBPII mutants induced a systematic shift in the absorption profile of all-trans-retinal of more than 200 nanometers across the visible spectrum. PMID: 23224553
    5. retinoic acid responsiveness of the human CRBP II promoter is mediated by an indirect mechanism and that this mechanism is associated with enterocyte differentiation. PMID: 12016134
    6. We report here the X-ray structures of human apo and holo CRBP II solved at 1.2 A resolution and compare the two structures between them and with the structures of zebrafish and rat CRBP II. PMID: 18076076
    7. HNF-4alpha is an important transcriptional factor that regulates human CRBPII gene expression; possibility for a novel function of HNF-4alpha in the regulation of human intestinal vitamin A absorption and metabolism PMID: 19147806

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Calycin superfamily, Fatty-acid binding protein (FABP) family
  • 组织特异性：
    Higher expression in adult small intestine and to a much lesser extent in fetal kidney.
  • 数据库链接：

    HGNC: 9920

    OMIM: 180280

    KEGG: hsa:5948

    STRING: 9606.ENSP00000232217

    UniGene: Hs.655516