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RCBTB1 Antibody

  • 货号：
    CSB-PA030187
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q8NDN9
  • 基因名：
    RCBTB1
  • 别名：
    Chronic lymphocytic leukemia deletion region gene 7 protein antibody; CLL deletion region gene 7 protein antibody; CLLL7 antibody; CLLL7 protein antibody; E4.5 antibody; GDP/GTP exchange factor (GEF) like protein antibody; GLP antibody; Guanine nucleotide exchange factor antibody; Hypothetical protein FLJ39335 antibody; RCBT1_HUMAN antibody; Rcbtb1 antibody; RCC1 and BTB domain-containing protein 1 antibody; Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 antibody; Regulator of chromosome condensation and BTB domain-containing protein 1 antibody; RP11-185C18.1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human CLLD7.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May be involved in cell cycle regulation by chromatin remodeling.
  • 基因功能参考文献：
    1. Data indicate RNA Binding Protein with Multiple Splicing (RBPMS), Regulator of Chromosome Condensation and POZ Domain Containing Protein 1 (RCBTB1), and Zinc Finger protein 608 (ZNF608) as miR-21-3p target genes. PMID: 27166999
    2. study puts forward mutations in RCBTB1 as a cause of autosomal-recessive non-syndromic and syndromic inherited retinal dystrophies; data support a role for impaired ubiquitination in the pathogenetic mechanism of RCBTB1 mutations PMID: 27486781
    3. Results identified RCBTB1 as a gene associated with vitreoretinopathy and found that it plays a role in retinal angiogenesis through Norrin-induced beta-catenin signaling. PMID: 26908610
    4. Study identifies RCBTB1 as a modifier of the smoking effect on carotid intima-media thickness. PMID: 24202307
    5. Data show that the biological actions of Clld7 are consistent with those of a tumor suppressor. PMID: 20926398
    6. E4.5 gene, which maps at chromosome band 13q14.3, encodes for a 4 kb mRNA expressed in various tissues and has an open reading frame of 531 amino acids. It has a potential role in the pathogenesis of chronic lymphocytic leukemia [E4.5] PMID: 14565662

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  • 相关疾病：
    Retinal dystrophy with or without extraocular anomalies (RDEOA)
  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Ubiquitously expressed. In the retina, present in the nerve fiber layer and to a lesser extent in the inner and outer plexiform layers (at protein level).
  • 数据库链接：

    HGNC: 18243

    OMIM: 607867

    KEGG: hsa:55213

    STRING: 9606.ENSP00000258646

    UniGene: Hs.508021