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RDH11 Antibody

  • 货号：
    CSB-PA019523LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: RDH11 antibody at 10µg/ml
      Lane 1: PC-3 whole cell lysate
      Lane 2: Hela whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 36, 35, 28 kDa
      Observed band size: 36 kDa
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA019523LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA019523LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) RDH11 Polyclonal antibody
  • Uniprot No.：
    Q8TC12
  • 基因名：
    RDH11
  • 别名：
    Androgen regulated short chain dehydrogenase/reductase 1 antibody; Androgen-regulated short-chain dehydrogenase/reductase 1 antibody; ARSDR1 antibody; AU045252 antibody; C85936 antibody; CGI 82 antibody; FLJ32633 antibody; HCBP12 antibody; HCV core binding protein antibody; HCV core binding protein HCBP12 antibody; HCV core-binding protein HCBP12 antibody; MDT1 antibody; Prostate short chain dehydrogenase/reductase 1 antibody; Prostate short-chain dehydrogenase/reductase 1 antibody; PSDR1 antibody; RALR1 antibody; RDH11 antibody; RDH11_HUMAN antibody; Retinal reductase 1 antibody; retinol dehydrogenase 11 (all trans/9 cis/11 cis) antibody; Retinol dehydrogenase 11 antibody; SCALD antibody; SDR7C1 antibody; Short chain dehydrogenase/reductase family 7C; member 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Retinol dehydrogenase 11 protein (22-318AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，RDH11 Antibody (CSB-PA019523LA01HU)，的标记方式是Non-conjugated。对于RDH11 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA019523LB01HU RDH11 Antibody, HRP conjugated ELISA
    FITC CSB-PA019523LC01HU RDH11 Antibody, FITC conjugated
    Biotin CSB-PA019523LD01HU RDH11 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Retinol dehydrogenase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinol, and to a lesser extent on 13-cis-retinol. Exhibits a low reductive activity towards unsaturated medium-chain aldehydes such as cis -6-nonenal and no activity toward nonanal or 4-hydroxy-nonenal. Has no dehydrogenase activity towards steroid.
  • 基因功能参考文献：
    1. Data suggest that membrane anchoring of retinol dehydrogenase 11 (RDH11) is likely driven by its N-terminal segment. PMID: 25542782
    2. Data indicate that ribosomal protein L11 (RPL11)-expressing cells proliferated more rapidly than the ribosomal protein L11 (RPL11)-expressing cells. PMID: 25829192
    3. deleterious mutations in RDH11, an important enzyme for vision-related and systemic retinoic acid metabolism, cause a new syndrome with RP. PMID: 24916380
    4. Prostate short-chain dehydrogenase/reductase (PSDR1) encodes a novel retinal reductase (RalR1). PMID: 12036956
    5. The core protein of HCV can interact with translin protein. This can partly explain the molecular mechanism for hepatocellular carcinoma and lymphoma caused by HCV. PMID: 12532453
    6. Expression pattern and high catalytic efficiency of RalR1 are consistent with the hypothesis that RalR1 contributes to the reduction of retinal in various human tissues. PMID: 14674758
    7. RDH11 localizes to photoreceptor inner segments [review] PMID: 17249616

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  • 相关疾病：
    Retinal dystrophy, juvenile cataracts, and short stature syndrome (RDJCSS)
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Short-chain dehydrogenases/reductases (SDR) family
  • 组织特异性：
    Predominantly expressed in the epithelial cells of prostate, in both basal and luminal secretory cell populations. Expressed at low levels in spleen, thymus, testis, ovary, small intestine, colon, peripherical blood leukocytes, kidney, adrenal gland and f
  • 数据库链接：

    HGNC: 17964

    OMIM: 607849

    KEGG: hsa:51109

    STRING: 9606.ENSP00000370750

    UniGene: Hs.719925