Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. RER1 Antibody

RER1 Antibody

  • 货号：
    CSB-PA019567LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA019567LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA019567LA01HU at dilution of 1:100
    • Immunofluorescent analysis of 293T cells using CSB-PA019567LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) RER1 Polyclonal antibody
  • Uniprot No.：
    O15258
  • 基因名：
    RER1
  • 别名：
    RER1; Protein RER1
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Protein RER1 protein (85-139AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，RER1 Antibody (CSB-PA019567LA01HU)，的标记方式是Non-conjugated。对于RER1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA019567LB01HU RER1 Antibody, HRP conjugated ELISA
    FITC CSB-PA019567LC01HU RER1 Antibody, FITC conjugated
    Biotin CSB-PA019567LD01HU RER1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.
  • 基因功能参考文献：
    1. RER1 is a novel and potential important mediator of elevated alphaSyn levels PMID: 28877262
    2. Rer1p regulates the ER retention of immature or misfolded rhodopsin and modulates its intracellular trafficking through the early secretory pathway. PMID: 25096327
    3. Charcot-Marie-Tooth disease-related PMP22 is trapped in the endoplasmic reticulum by calnexin-dependent retention and Rer1-mediated early Golgi retrieval systems and partly degraded by the Hrd1-mediated endoplasmic reticulum-associated degradation system. PMID: 25385046
    4. Rer1p depletion reduced ciliary length and function by increasing gamma-secretase complex assembly and activity and, consequently, enhancing Notch signaling as well as reducing Foxj1a expression. PMID: 23479743
    5. Synoviolin up-regulates amyloid beta production by targeting a negative regulator of gamma-secretase, Rer1, for degradation. PMID: 23129766
    6. RER1 modulates amyloid-beta production by altering trafficking of gamma-secretase and amyloid precursor protein. PMID: 23043097
    7. Downregulation of Rer1 leads to increased surface localization of Pen2, whereas overexpression of Rer1 stabilizes unassembled Pen2. Rer1 is the first identified interaction partner of mammalian transmembrane-based retention/retrieval signals. PMID: 17668005

    显示更多

    收起更多

  • 亚细胞定位：
    Golgi apparatus membrane; Multi-pass membrane protein.
  • 蛋白家族：
    RER1 family
  • 数据库链接：

    HGNC: 30309

    KEGG: hsa:11079

    STRING: 9606.ENSP00000302088

    UniGene: Hs.525527