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  4. RFC3 Antibody

RFC3 Antibody

  • 货号：
    CSB-PA019590GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P40938
  • 基因名：
  • 别名：
    A1 38 kDa subunit antibody; Activator 1 38 kDa subunit antibody; Activator 1 subunit 3 antibody; HGNC:9971 antibody; MGC5276 antibody; Replication factor C (activator 1) 3 antibody; Replication factor C (activator 1) 3, 38kDa antibody; Replication factor C 3 antibody; Replication factor C 38 kDa subunit antibody; Replication factor C subunit 3 antibody; RF-C 38 kDa subunit antibody; RFC 38 kD subunit antibody; RFC 38 kDa subunit antibody; RFC3 antibody; RFC3_HUMAN antibody; RFC38 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human RFC3
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.
  • 基因功能参考文献：
    1. The expression level of RFC3 was markedly upregulated in the HCC tissues and cells. PMID: 26397132
    2. The expression level of RFC3 was remarkably up-regulated in ovarian cancer OVCAR-3 cells. Down-regulation of RFC3 expression arrested the cell cycle of OVCAR-3 cell in the S-phase and induced apoptosis. PMID: 26464638
    3. High RFC3 expression is associated with neoplastic myelopoiesis. PMID: 25541153
    4. our findings suggest that RFC3 protein is an important and independent biomarker with prognostic implications for patients with ovarian carcinoma. PMID: 25030735
    5. 9-cis-RA-activated RXRalpha suppresses the growth of retinoid-sensitive breast cancer and embryonic cells through RFC3. PMID: 22949521
    6. Data identified RFC3 as a candidate oncogene amplified in esophageal adenocarcinoma (EAC). PMID: 22328562
    7. RFC3 mutation and loss of RFC3 expression occur in large fractions of gastric and colorectal cancers and suggest that these alterations may contribute to the cancer pathogenesis by deregulating DNA repair and replication. PMID: 20573375

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Activator 1 small subunits family
  • 数据库链接：

    HGNC: 9971

    OMIM: 600405

    KEGG: hsa:5983

    STRING: 9606.ENSP00000369411

    UniGene: Hs.115474