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RFTN1 Antibody

  • 货号：
    CSB-PA008331
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of 3T3 cells using Raftlin Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q14699
  • 基因名：
    RFTN1
  • 别名：
    RFTN1 antibody; KIAA0084 antibody; MIG2 antibody; Raftlin antibody; Cell migration-inducing gene 2 protein antibody; Raft-linking protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human Raftlin.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in protein trafficking via association with clathrin and AP2 complex. Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion. May regulate B-cell antigen receptor-mediated signaling. May play a pivotal role in the formation and/or maintenance of lipid rafts.
  • 基因功能参考文献：
    1. this study shows that raftlin appears to modulate cargo selection as an accessary protein of clathrin-associated adaptor protein-2 in clathrin-mediated endocytosis of TLR3/4 ligands PMID: 27022195
    2. Mitogen-inducible Gene-2 expression is reduced in breast cancer. PMID: 23645746
    3. combination of ATOH7 and RFTN1 SNPs increased risk to POAG, indicating their diversified effects in the complex genetics of glaucoma. PMID: 22222511
    4. Raftlin cooperates with the uptake receptor to mediate cell entry of poly(I:C), which is critical for activation of TLR3. PMID: 21266579
    5. These data suggest that Raftlin plays a pivotal role in the formation and/or maintenance of lipid rafts, therefore regulating B-cell antigen receptor-mediated signaling. PMID: 12805216

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor. Cytoplasm. Membrane raft. Endosome. Early endosome.
  • 蛋白家族：
    Raftlin family
  • 组织特异性：
    Expressed in B-cells (at protein level). Expressed in dendritic cells and macrophages.
  • 数据库链接：

    HGNC: 30278

    KEGG: hsa:23180

    STRING: 9606.ENSP00000334153

    UniGene: Hs.98910