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RGS12 Antibody

  • 货号：
    CSB-PA040214
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of 3T3 cells using RGS12 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    O14924
  • 基因名：
    RGS12
  • 别名：
    RGS12 antibody; Regulator of G-protein signaling 12 antibody; RGS12 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human RGS12.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form.; Behaves as a cell cycle-dependent transcriptional repressor, promoting inhibition of S-phase DNA synthesis.
  • 基因功能参考文献：
    1. Findings identify RGS12 as a candidate tumor-suppressor gene in AA prostate cancer, which acts by decreasing expression of AKT and MNX1, establishing a novel oncogenic axis in this disparate disease setting. PMID: 28611045
    2. Data support the notion that the Galpha, but not Gbetagamma, arm of the Gi/o signalling is involved in TRPC4 activation and unveil new roles for RGS and RGS12 in fine-tuning TRPC4 activities. PMID: 26987813
    3. RGS12 is essential for the terminal differentiation of osteoclasts induced by RANKL. PMID: 17042716
    4. shows chromosomal mapping information for human locus. PMID: 9168931
  • 亚细胞定位：
    Nucleus. Cytoplasm. Cell projection, dendrite. Cell junction, synapse.; [Isoform 5]: Nucleus matrix.
  • 组织特异性：
    Isoform 3 is brain specific.
  • 数据库链接：

    HGNC: 9994

    OMIM: 602512

    KEGG: hsa:6002

    STRING: 9606.ENSP00000339381

    UniGene: Hs.527061