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RGS7 Antibody

  • 货号：
    CSB-PA019659ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA019659ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA019659ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) RGS7 Polyclonal antibody
  • Uniprot No.：
    P49802
  • 基因名：
    RGS7
  • 别名：
    RGS7 antibody; Regulator of G-protein signaling 7 antibody; RGS7 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Regulator of G-protein signaling 7 protein (1-300AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS7/GNB5 dimer enhances GNAO1 GTPase activity. May play a role in synaptic vesicle exocytosis. Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling.
  • 基因功能参考文献：
    1. Results found that RGS7 was mutated in 11% of melanomas with three recurrent mutations (p.R44C, p.E383K and p.R416Q). p.R44C was shown to destabilize the protein due to the loss of an H-bond and salt bridge. RGS7 p.R44C has weaker catalytic activity for its substrate Galphao, thus providing a dual mechanism for its loss of function resulting in increase anchorage-independent growth, migration and invasion of melanoma c... PMID: 29330521
    2. Data (including data from studies using transgenic mice) suggest that R7BP-RGS7 heterotrimers interact with Galpha13 to augment signaling pathways in neurons that regulate neurite morphogenesis. (R7BP = RGS7 family binding protein; RGS7 = regulator of G-protein signaling 7 protein; Galpha13 = GTP-binding protein alpha subunit 13) PMID: 28432124
    3. R7-binding protein had a strong inhibitory effect on homo-oligomerization of RGS7. PMID: 26895961
    4. Fine mapping of the uterine leiomyoma locus on 1q43 close to a lncRNA in the RGS7-FH interval PMID: 26113603
    5. New single nucleotide polymorphisms associated with differences in platelets reactivity in patients with type 2 diabetes treated with acetylsalicylic acid: genome-wide association approach and pooled DNA strategy. PMID: 23054467
    6. the GAP activity of RGS9-2 showed a strong receptor preference for D2R over MOR. Finally, RGS7 displayed an four times greater GAP activity relative to RGS9-2. PMID: 23857581
    7. Gi/o signaling and the palmitoyltransferase DHHC2 regulate palmitate cycling and shuttling of RGS7 family-binding protein. PMID: 21343290
    8. tumor necrosis factor-alpha regulates the interaction of RGS7 with 14-3-3 PMID: 12077120
    9. could play a role in synaptic vesicle exocytosis through its interaction with snapin PMID: 12659861
    10. Galpha-regulated plasma membrane localization and palmitoylation of RGS7. PMID: 15496508
    11. cytoplasmic RGS7*Gbeta5*R7BP heterotrimers and RGS7*Gbeta5 heterodimers are equivalently inefficient regulators of G protein-coupled receptor signaling relative to plasma membrane-bound heterotrimers bearing palmitoylated R7BP. PMID: 16867977
    12. The DEP domain of RGS7 can directly bind to the third intracellular loop of the M3R and attenuate receptor-induced Ca2+ mobilization in a M3 subtype-selective manner. PMID: 19182865
    13. cytosolic chaperonin complex-dependent mechanism exists for Gbeta5-RGS7 assembly that utilizes the co-chaperone activity of PhLP1 in a unique way PMID: 19376773
    14. common variation within the RGS7 locus may be involved in multiple sclerosis susceptibility. PMID: 19626040

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  • 亚细胞定位：
    Cytoplasm, cytosol. Cytoplasm. Cell membrane. Membrane; Peripheral membrane protein; Cytoplasmic side.
  • 数据库链接：

    HGNC: 10003

    OMIM: 602517

    KEGG: hsa:6000

    STRING: 9606.ENSP00000355523

    UniGene: Hs.655739