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RGS9 Antibody

  • 货号：
    CSB-PA019662ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA019662ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human glioma using CSB-PA019662ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) RGS9 Polyclonal antibody
  • Uniprot No.：
    O75916
  • 基因名：
    RGS9
  • 别名：
    PERRS antibody; R9AP antibody; Regulator of G protein signalling 9 antibody; Regulator of G-protein signaling 9 antibody; RGS9 antibody; RGS9_HUMAN antibody; RGS9L antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Regulator of G-protein signaling 9 protein (230-350AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to GNAT1. Involved in phototransduction; key element in the recovery phase of visual transduction.
  • 基因功能参考文献：
    1. This case series highlights the clinical presentations and features of 5 affected children (3 Arab families) who harbored the same homozygous RGS9 frameshift mutation, which seems to represent a founder effect for the Arabian Peninsula. PMID: 29107794
    2. To identify single-nucleotide polymorphisms that contribute to the genetic susceptibility to schizophrenia, we examined the potential association between schizophrenia and 9 single nucleotide polymorphisms in the G-protein signaling 9 gene PMID: 26345773
    3. These findings indicate a role for RGS9 gene polymorphisms in heroin dependence and may be informative for future genetic or biological studies on heroin dependence. PMID: 25591550
    4. the GAP activity of RGS9-2 showed a strong receptor preference for D2R over MOR. Finally, RGS7 displayed an four times greater GAP activity relative to RGS9-2. PMID: 23857581
    5. These studies with humans, rats and mice implicate RGS9-2 as a factor in regulating body weight. PMID: 22132185
    6. beta-Arrestin2 is required for the inhibition of D3R signaling by RGS9-2. PMID: 22006018
    7. Type 5 G protein beta subunit (Gbeta5) controls the interaction of regulator of G protein signaling 9 (RGS9) with membrane anchors PMID: 21511947
    8. The main goal of this review is to illustrate how various functions are fulfilled through the interplay between the intrinsic molecular properties of RGS9 isoforms. PMID: 20374717
    9. The expression of RGS9-2 inhibits dopamine-mediated cellular internalization of the dopamine 2 (D2) receptor. PMID: 20477943
    10. no association with schizophrenia in an Israeli Jewish population PMID: 20016399
    11. This is the first report describing a nonsense mutation in RGS9. PMID: 19818506
    12. five unrelated patients with recessive mutations in the genes encoding either RGS9 or R9AP who report difficulty adapting to sudden changes in luminance levels mediated by cones PMID: 14702087
    13. under certain conditions, RGS9 and Gbeta5 may possibly function as betagamma dimer PMID: 15474482
    14. homozygous mutations in RGS9 gene that encodes the photoreceptor GTPase accelerating protein and its anchor protein, respectively, have been identifird in patients with bradyopsia. PMID: 17698770
    15. In the haplotype analysis, a significant association of the AGG haplotype (rs8077696-rs8070231-rs2292593) of the RGS9 gene was found (permutation P = 0.007) PMID: 18548510

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  • 相关疾病：
    Prolonged electroretinal response suppression (PERRS)
  • 亚细胞定位：
    [Isoform 3]: Membrane; Peripheral membrane protein.
  • 组织特异性：
    Highly expressed in the caudate and putamen, lower levels found in the hypothalamus and nucleus accumbens and very low levels in cerebellum. Not expressed in globus pallidus or cingulate cortex. Isoform 2 is expressed predominantly in pineal gland and ret
  • 数据库链接：

    HGNC: 10004

    OMIM: 604067

    KEGG: hsa:8787

    STRING: 9606.ENSP00000262406

    UniGene: Hs.664380