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RHEBL1 Antibody

  • 货号：
    CSB-PA855034LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA855034LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human appendix tissue using CSB-PA855034LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) RHEBL1 Polyclonal antibody
  • Uniprot No.：
    Q8TAI7
  • 基因名：
    RHEBL1
  • 别名：
    RHEBL1 antibody; GTPase RhebL1 antibody; Ras homolog enriched in brain like-1 c antibody; RhebL1c antibody; Ras homolog enriched in brain-like protein 1 antibody; Rheb-like protein 1 antibody; Rheb2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human GTPase RhebL1 protein (1-180AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，RHEBL1 Antibody (CSB-PA855034LA01HU)，的标记方式是Non-conjugated。对于RHEBL1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA855034LB01HU RHEBL1 Antibody, HRP conjugated ELISA
    FITC CSB-PA855034LC01HU RHEBL1 Antibody, FITC conjugated
    Biotin CSB-PA855034LD01HU RHEBL1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2.
  • 基因功能参考文献：
    1. High RHEBL1 expression is associated with lung cancer. PMID: 28209923
    2. These results establish CAD as a downstream effector of Rheb and suggest a possible role of Rheb in regulating de novo pyrimidine nucleotide synthesis.(Rheb small GTPases, which consist of Rheb1 and Rheb2 (also known as RhebL1) PMID: 25422319
    3. RhebL1 may be impacting the mTOR pathway in a different manner than Rheb1. PMID: 21655954
    4. Data show that Rheb like-1 protein (RhebL1) rescues mTOR signaling during nutrient withdrawal, and identify critical residues in Rheb and RhebL1 which are required for their efficient activation of mTOR signaling. PMID: 16098514
    5. RHEBL1 is a positive regulator of NF-kappa B-mediated gene transcription. PMID: 16328882

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  • 亚细胞定位：
    Endomembrane system; Lipid-anchor; Cytoplasmic side. Cytoplasm.
  • 蛋白家族：
    Small GTPase superfamily, Rheb family
  • 组织特异性：
    Ubiquitously expressed. Expression increased at least 2-fold in several tumor cell lines.
  • 数据库链接：

    HGNC: 21166

    KEGG: hsa:121268

    STRING: 9606.ENSP00000301068

    UniGene: Hs.159013