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RILP Antibody

  • 货号：
    CSB-PA850399LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA850399LA01HU diluted at 1:500 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) RILP Polyclonal antibody
  • Uniprot No.：
    Q96NA2
  • 基因名：
    RILP
  • 别名：
    FLJ31193 antibody; PP10141 antibody; Rab interacting lysosomal protein antibody; Rab-interacting lysosomal protein antibody; Rilp antibody; RILP_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Rab-interacting lysosomal protein (307-385AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，RILP Antibody (CSB-PA850399LA01HU)，的标记方式是Non-conjugated。对于RILP Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA850399LB01HU RILP Antibody, HRP conjugated ELISA
    FITC CSB-PA850399LC01HU RILP Antibody, FITC conjugated
    Biotin CSB-PA850399LD01HU RILP Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Rab effector playing a role in late endocytic transport to degradative compartments. Involved in the regulation of lysosomal morphology and distribution. Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments. Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes.
  • 基因功能参考文献：
    1. Hepatitis C virus (HCV) modifies cellular trafficking by cleaving Rab interacting lysosomal protein (RILP), which serves to redirect ras-related protein Rab-7 (Rab7)-containing vesicles to a kinesin-dependent trafficking mode promoting virion secretion. PMID: 27791088
    2. RILP suppresses the invasion of breast cancer cells by interacting with RalGDS to inhibit its guanine nucleotide exchange factor activity for RalA. PMID: 26469971
    3. RILP regulates vacuolar ATPase through interaction with the V1G1 subunit PMID: 26180254
    4. VPS41 subunit of HOPS complex was defined to be the major partner for interacting with RILP. PMID: 25445562
    5. RILP regulates the activity of the V-ATPase through its interaction with V1G1. PMID: 24762812
    6. RILP directly and concomitantly binds the tethering HOPS complex and the p150(Glued) subunit of the dynein motor. ORP1L then functions as a cholesterol-sensing switch controlling RILP-HOPS-p150(Glued) interactions. PMID: 23729732
    7. Unique region in RILP responsible for its specific role in regulating lysosomal morphology as well as in its interaction with Rab7 and Rab34. PMID: 14668488
    8. The crystal structure of Rab7-GTP in complex with the Rab7 binding domain of RILP reveals that Rab7 interacts with RILP specifically via two distinct areas. PMID: 15933719
    9. The data together indicate that RILP, as already demonstrated for several other Rab effector proteins, is capable of self-association, thus probably forming a homo-dimer. PMID: 15996637
    10. RILP indeed prenylated, while phosphorylation analysis showed that the two protein kinase A sites are phosphorylated. PMID: 16417580
    11. Hence, RILPsv provides an extra dimension to the control of vesicle fusion and transport by the small GTPase Rab7. PMID: 16631113
    12. we have isolated, using the yeast two-hybrid system, the EAP30/SNF8/VPS22 subunit of the ESCRT-II complex as a RILP interacting protein. PMID: 16857164
    13. These results establish that RILP is required for biogenesis of multivesicular endosomes and degradative trafficking of EGFRs but not for trafficking of transferrin receptors through early endosomes. PMID: 17959629
    14. REST/NRSF, dynactin p150(Glued), huntingtin, HAP1, and RILP form a complex involved in the translocation of REST/NRSF into the nucleus and HAP1 controls REST/NRSF cellular localization in neurons PMID: 18922795
    15. Results describe how ORP1L contacts VAP to control Rab7-RILP-p150 Glued and late endosome positioning. PMID: 19564404

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  • 亚细胞定位：
    Late endosome membrane. Lysosome membrane. Cytoplasmic vesicle, phagosome membrane.
  • 组织特异性：
    Ubiquitous. Strongly expressed in fetal heart, heart, stomach, spleen, adrenal gland, thyroid gland, salivary gland, fetal liver, liver and lung. Poorly expressed in brain.
  • 数据库链接：

    HGNC: 30266

    OMIM: 607848

    KEGG: hsa:83547

    STRING: 9606.ENSP00000301336

    UniGene: Hs.534497