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RIN3 Antibody

  • 货号：
    CSB-PA004010
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of K562 cells using RIN3 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q8TB24
  • 基因名：
    RIN3
  • 别名：
    RIN3 antibody; Ras and Rab interactor 3 antibody; Ras interaction/interference protein 3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human RIN3.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function.
  • 基因功能参考文献：
    1. RIN3 may be involved in endolysosomal transport-a process known to be important to development of early onset AD. PMID: 28738127
    2. RIN3 may contribute to Paget's disease of bone susceptibility by affecting osteoclast function. PMID: 25701875
    3. discovered novel interaction candidates for CD2AP and characterized subtle yet significant differences in the recognition preferences of its three SH3 domains for c-CBL, ALIX, and RIN3 PMID: 26296892
    4. The study reports a novel association between a variant within RIN3 and lower limb-bone mineral density and note its previous association with risk of Paget's disease. PMID: 24945404
    5. RIN3 is a negative regulator of mast cell responses to SCF PMID: 23185384
    6. RIN3 specifically acts as a GEF for Rab31. PMID: 21586568
    7. RIN3 biochemically characterized as the stimulator and stabilizer for GTP-Rab5 plays an important role in the transport pathway from plasma membrane to early endosomes PMID: 12972505
    8. Tyrosine-phosphorylation signals are involved in the RIN3 activation and translocation to early endocytic vesicles. PMID: 18486601

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  • 亚细胞定位：
    Cytoplasm. Cytoplasmic vesicle. Early endosome.
  • 蛋白家族：
    RIN (Ras interaction/interference) family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 18751

    OMIM: 610223

    KEGG: hsa:79890

    STRING: 9606.ENSP00000216487

    UniGene: Hs.326822