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RINT1 Antibody

  • 货号：
    CSB-PA019731GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q6NUQ1
  • 基因名：
    RINT1
  • 别名：
    DKFZp667H2324 antibody; FLJ11785 antibody; HsRINT 1 antibody; HsRINT-1 antibody; HsRINT1 antibody; RAD50 interacting protein 1 antibody; RAD50 interactor 1 antibody; RAD50-interacting protein 1 antibody; RINT 1 antibody; RINT-1 antibody; RINT1 antibody; RINT1_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human RINT1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER. May play a role in cell cycle checkpoint control. Essential for telomere length control.
  • 基因功能参考文献：
    1. Study presents evidence that in the Caucasian population, RINT1 does not represent a moderate- penetrance breast cancer susceptibility gene, and find no evidence to support an association of RINT1 mutation with Lynch syndrome-related cancer incidence in breast cancer families. PMID: 27544226
    2. these data are more consistent with the hypothesis that RINT1 functions as an oncogene rather than a tumor suppressor gene in the context of colorectal cancer. PMID: 28264000
    3. HPV E2 protein targets Rad50-interacting protein 1 (Rint1) to facilitate virus genome replication. PMID: 28031358
    4. RINT-1 interacts with MSP58 and UBF within nucleoli and plays a role in ribosomal gene transcription. PMID: 27530925
    5. Results suggest that high RAD50 interactor 1 (RINT1) expression may represent a risk factor for low-grade gliomas (LGGs)-related seizures. PMID: 25304616
    6. Results identified RINT1 as a putative breast cancer predisposition gene that also seems to be associated with risk for a spectrum of other cancers similar to those that have previously been described for Lynch syndrome. PMID: 25050558
    7. RINT-1 is also required for endosome-to-trans-Golgi network trafficking. PMID: 23885118
    8. RINT1 was validated as a novel glioblastoma oncogene PMID: 23074196
    9. These findings suggest that RINT-1 serves as a novel tumor suppressor essential for maintaining the dynamic integrity of the Golgi apparatus and the centrosome, a prerequisite to their proper coordination during cell division. PMID: 17470549
    10. Rab6 regulates distinct Golgi trafficking pathways involving two separate protein complexes: ZW10/RINT-1 and COG. PMID: 17699596

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  • 亚细胞定位：
    Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein.
  • 蛋白家族：
    RINT1 family
  • 数据库链接：

    HGNC: 21876

    OMIM: 610089

    KEGG: hsa:60561

    STRING: 9606.ENSP00000257700

    UniGene: Hs.531388