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RIT1 Antibody

  • 货号：
    CSB-PA004013
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of Jurkat cells using Rit1 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q92963
  • 基因名：
  • 别名：
    GTP binding protein Roc1 antibody; GTP-binding protein Rit1 antibody; NS8 antibody; Ras like protein expressed in many tissues antibody; Ras like without CAAX 1 antibody; Ras-like protein expressed in many tissues antibody; Ras-like without CAAX protein 1 antibody; RIBB antibody; Ric like expressed in many tissues antibody; Ric-like protein without CAAX motif 1 antibody; RIT antibody; RIT1 antibody; RIT1_HUMAN antibody; ROC1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human Rit1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation.
  • 基因功能参考文献：
    1. The functional assessment supported the pathogenicity of the RAF1 and RIT1 variants of unknown significance (VUSs), while the significance of two VUSs in A2ML1 remained unclear. PMID: 29402968
    2. Our report contributes to the delineation of the phenotype associated with RIT1 mutations and underlines that lymphatic involvement is part of this spectrum PMID: 27109146
    3. RIT1 is one of the major genes for NS. The RIT1-associated phenotype differs gradually from other NS subtypes, with a high prevalence of cardiovascular manifestations, especially hypertrophic cardiomyopathy. PMID: 27101134
    4. Congenital left main coronary artery atresia in a Noonan syndrome is associated with RIT1 variant, leading to unrescued sudden death. PMID: 28347726
    5. Noonan patients with germline RIT1 mutations are not at high risk to developing JMML or ALL, and that RIT1 has at most a marginal role in these sporadic malignancies. PMID: 26757980
    6. Biochemical Classification of Disease-associated Mutants of RAS-like Protein Expressed in Many Tissues (RIT1). PMID: 27226556
    7. We report on a 2.5-year-old male patient with clinical signs of NS and hematologic abnormalities, in whom a novel heterozygous substitution in RIT1 with probable pathogenicity was detected. PMID: 26518681
    8. Mutations in RIT1 cause Noonan syndrome. Mutations in RIT1 affect RAS-MAPK/MEK-ERK signaling. The mutant RIT1 protein may possess reduced GTPase activity or a diminished ability to interact with cellular GTPase activating proteins. PMID: 25959749
    9. elevated expression of RIT1 may contribute to the progression of endometrial cancer and thus may serve as a novel prognostic marker and a promising molecular target for the treatment of endometrial cancer. PMID: 26617739
    10. Because of the relatively high frequency of mutations in RIT1 among patients with NS and its occurrence in different populations, we suggest that it should be added to the list of genes included in panels for the molecular diagnosis of NS. PMID: 25124994
    11. A genotype-phenotype correlation analysis of available records indicated that germline RIT1 mutations cause a noonan syndrome phenotype characterized by a mild facial appearance. PMID: 26714497
    12. four additional cases of Noonan syndrome with mutations in RIT1, were identified. PMID: 24939608
    13. Data identify RIT1 as a driver oncogene in a specific subset of lung adenocarcinomas. PMID: 24469055
    14. we highlight recent studies using transgenic and knockout animal models which have begun to elucidate the physiological roles for the Rit subfamily, including emerging roles in the regulation of neuronal morphology and cellular survival signaling PMID: 23770287
    15. ROC1 knockdown remarkably inhibited bladder cancer cell growth, arrested cells at the G2 phase of the cell cycle, and induced the p53-dependent cell senescence. PMID: 23667514
    16. study demonstrates that RIT1 abnormalities, including activating mutations and locus amplifications, are novel lesions in a subgroup of patients with myeloid neoplasms, particularly frequent in chronic myelomonocytic leukemia PMID: 23765226
    17. Five RIT1 alterations identified in children with Noonan syndrome enhanced ELK1 transactivation. PMID: 23791108
    18. the present studies identify a critical role for the Rit-p38 MAPK signaling cascade in promoting hippocampal neuron survival following oxidative stress PMID: 23123784
    19. the Rit-p38-MSK1/2 signaling pathway may have an important role in the stress-dependent regulation of CREB-dependent gene expression. PMID: 23038261
    20. the studies establish Rit as a central regulator of a p38 MAPK-dependent signaling cascade that functions as a critical cellular survival mechanism in response to stress PMID: 21444726
    21. Rit plays a key role in human neuronal development and regeneration through activating both known and as yet undefined signaling pathways PMID: 12668729
    22. Gene amplification is one of the main activating ways of RIT1 gene in hepatocellular carcinoma (HCC), and its amplification might be correlated with HCC carcinogenesis, while point mutation might be not. PMID: 14767908

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  • 相关疾病：
    Noonan syndrome 8 (NS8)
  • 亚细胞定位：
    Cell membrane.
  • 蛋白家族：
    Small GTPase superfamily, Ras family
  • 组织特异性：
    Expressed in many tissues.
  • 数据库链接：

    HGNC: 10023

    OMIM: 609591

    KEGG: hsa:6016

    STRING: 9606.ENSP00000357306

    UniGene: Hs.491234