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RMI1 Antibody

  • 货号：
    CSB-PA019754GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9H9A7
  • 基因名：
    RMI1
  • 别名：
    BLAP75 antibody; BLM associated polypeptide 75 kDa antibody; BLM associated protein 75 kDa antibody; BLM-associated protein of 75 kDa antibody; C9orf76 antibody; FAAP75 antibody; FLJ12888 antibody; Homolog of yeast RecQ mediated genome instability 1 antibody; RecQ mediated genome instability 1 antibody; RecQ-mediated genome instability protein 1 antibody; Rmi1 antibody; RMI1 homolog antibody; RMI1 RecQ mediated genome instability 1 homolog antibody; RMI1_HUMAN antibody; RP11-346I8 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human RMI1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.
  • 基因功能参考文献：
    1. RMI1 knockdown cells exhibit accumulation of broken DNAs after being released from hydroxyurea treatment. Moreover, we demonstrate that RMI1 facilitates the recovery from activated checkpoint and resuming the cell cycle after replicative stress. PMID: 29042194
    2. RMI1 protein level does not change through G1, S and G2 phases, but significantly increases in M phase. PMID: 26556339
    3. a model that maps all functionally important structural features for yeast Rmi1 and structure-prediction-based alignment with the recently established crystal structure of the N-terminus of human Rmi1, is proposed. PMID: 26717309
    4. The results show that Topo IIIalpha stimulates DNA unwinding by BLM in a manner that is potentiated by RMI1-RMI2, and that the processivity of resection is reliant on the Topo IIIalpha-RMI1-RMI2 complex. PMID: 25200081
    5. two proteins that interact with BLM, RMI1 and RMI2, are phosphorylated upon SAC activation, and, like BLM, RMI1, and RMI2, are phosphorylated in an MPS1-dependent manner. PMID: 24108125
    6. RMI1 is required to promote normal replication fork progression PMID: 22645306
    7. Crystal structures of RMI1 and RMI2, two OB-fold regulatory subunits of the BLM complex PMID: 20826342
    8. human topoisomerase IIIalpha functions as a decatenase with the assistance of BLM and RMI1 to facilitate the processing of homologous recombination intermediates without crossing over as a mechanism to preserve genome integrity PMID: 20445207
    9. No evidence was found for an association between RMI1 S455N (rs1982151) and colorectal cancer risk. PMID: 19945966
    10. BLAP75/RMI1 acts by recruiting TOPO IIIalpha to double Holliday junctions PMID: 16537486
    11. BLM, Topo IIIalpha, and BLAP75 constitute a dissolvasome complex that processes HR intermediates to limit DNA crossover formation PMID: 16595695
    12. BLM is stably associated with RMI1 protein. PMID: 17728255
    13. Genetic variant of the human homologous recombination-associated gene RMI1 is associated with acute myeloid leukemia, myelodysplatic syndromes and malignant melanoma PMID: 17900800
    14. evolutionarily conserved N-terminal third of BLAP75 mediates complex formation with BLM and Topo IIIalpha and that the DNA binding activity resides in the C-terminal third of this novel protein. PMID: 18390547
    15. Individuals carrying genetic variants of the BLM-TOP3A-RMI1 complex have an increased risk of acute myeloid leukemia/myelodysplatic syndromes, malignant melanoma, bladder and breast cancer. PMID: 19432957

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  • 亚细胞定位：
    Nucleus. Note=Forms foci in response to DNA damage.
  • 蛋白家族：
    RMI1 family
  • 数据库链接：

    HGNC: 25764

    OMIM: 610404

    KEGG: hsa:80010

    STRING: 9606.ENSP00000317039

    UniGene: Hs.726327